| Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response. | |
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MedLine Citation:
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PMID: 9230746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Viral infections have been associated with cellular immune responses and production of Th-1 cytokines. Respiratory syncytial virus (RSV), however, induces virus-specific IgE, which might be a consequence of a Th-2-like activation. To test this hypothesis we quantified interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) in the supernatant of peripheral blood mononuclear cells cultured for 24 and 48 h in the presence or absence of phytohemaglutinin and pokeweed mitogen and the lymphocyte phenotypes to analyze subsets and their activation markers, from 15 hospitalized infants during an acute lower respiratory infection caused by RSV and 17 healthy control infants from 1 to 15 mo of age. Compared with the control infants, those infected with RSV had an increase in the number of B-cells (p < 0.02) and decreases in both CD8+ T-cells (p < 0.01) and activated CD8+/CD25+ suppressor/ cytotoxic T-cells (p < 0.007). In RSV-infected infants, IFN-gamma production was subtotally suppressed, whereas IL-4 production was decreased to a lesser degree, giving significantly (p < 0.001) increased IL-4/IFN-gamma ratio compared with that in the control infants. These findings suggest a predominant Th-z-like response in RSV-infected infants, which could explain some aspects of the immunopathogenesis of RSV infection and the RSV-specific and nonspecific IgE antibody responses observed. |
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Authors:
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M Román; W J Calhoun; K L Hinton; L F Avendaño; V Simon; A M Escobar; A Gaggero; P V Díaz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: 156 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-08-12 Completed Date: 1997-08-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 190-5 Citation Subset: AIM; IM |
Affiliation:
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Departmentos Medicina Experimental Oriente y Microbiología, Facultad de Medicina, Universidad de Chile, Hospital Roberto del Río, Santiago, Chile. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Viral
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blood Case-Control Studies Cells, Cultured Humans Infant Interferon-gamma / blood* Interleukin-4 / blood* Leukocytes, Mononuclear / immunology Lymphocyte Activation Lymphocyte Subsets / immunology Respiratory Syncytial Virus Infections / immunology* Respiratory Syncytial Viruses / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Viral; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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