Document Detail

Respiratory symptoms in rheumatoid arthritis: relation between high resolution CT findings and functional impairment.
MedLine Citation:
PMID:  15287534     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objectives of this study were to analyze the high resolution computed tomography (HRCT) findings in rheumatoid arthritis (RA) patients with respiratory symptoms and to evaluate the relation between the extent of HRCT findings and functional impairment as assessed by spirometry. MATERIALS AND METHODS: HRCT examination of the thorax and pulmonary function tests (PFTs) were performed in 34 RA patients with respiratory symptoms. Patients with smoking history or with emphysema evident on HRCT were excluded from the study. CT findings were assessed for the presence and pattern of abnormalities. Extent was scored based on the number of pulmonary segments involved. PFTs included forced expiratory flows (FEFs) and forced vital capacity (FVC). RESULTS: Bronchial wall thickening was detected in 29 of 34 RA patients (85%), small nodules in 24 patients (71%), and bronchial dilatation in 21 patients (62%). The extent of bronchial wall thickening correlated with FEF25-75, FEF75, and FEF50 (p<0.0001, respectively) (Spearman's rank correlation). Extent of small nodules correlated with FEF25-75, FEF50, and FEF25 (p<0.01, respectively). Stepwise regression analysis showed independent correlations of bronchial wall thickening with decreases in FEF25-75 and FEF75 (p<0.0001, both). Bronchial dilatation was also independently associated with a decrease in FVC (p<0.05). CONCLUSION: The most common HRCT findings in RA patients with respiratory symptoms are bronchial wall thickening and small nodules, and the extent of these findings correlates significantly with functional impairment.
Hiroshi Terasaki; Kiminori Fujimoto; Naofumi Hayabuchi; Yoshio Ogoh; Takaaki Fukuda; Nestor L Müller
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  22     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-08-03     Completed Date:  2004-11-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  179-85     Citation Subset:  IM    
Department of Radiology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.
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MeSH Terms
Aged, 80 and over
Arthritis, Rheumatoid / complications*
Bronchial Diseases / etiology,  physiopathology,  radiography*
Bronchiectasis / etiology,  physiopathology,  radiography
Lung Diseases / etiology,  physiopathology,  radiography
Middle Aged
Respiratory Function Tests
Respiratory Physiological Phenomena
Tomography, X-Ray Computed / methods

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