Document Detail

Respiratory symptoms and airway responsiveness in apparently healthy workers exposed to flour dust.
MedLine Citation:
PMID:  7925875     Owner:  NLM     Status:  MEDLINE    
Our aim was to measure the levels of exposure to wheat flour dust in a modern industrial bakery, and to assess the relationship between respiratory symptoms, sensitization to wheat flour antigens and airway responsiveness in the workforce. Forty four flour-exposed male workers and 164 unexposed controls were examined. Inspirable dust concentrations were measured using personal samplers. Respiratory symptoms were assessed by questionnaire, sensitization to wheat flour antigens by skin-prick tests, and methacholine airway challenge (MAC) test using an abbreviated method. Subjects were labelled MAC+ if forced expiratory volume in one second (FEV1) fell by 20% or more. The linear dose-response slope (DRS) was calculated as the percentage fall in FEV1 at last dose divided by the total dose administered. Inspirable dust concentrations were within acceptable limits in all working areas but one. The proportion of subjects with one or more symptoms and with airway hyperresponsiveness was significantly greater among flour-exposed workers than among controls. Using logistic or linear regression analysis, airway responsiveness was found to be strongly related to working at the bakery and to the baseline level of lung function. A positive skin-prick test was found in only 11% of flour-exposed workers and 6% of controls. In conclusion, our data show that despite exposure to relatively low concentration levels of inspirable flour dust, subjects working in the baking industry are at risk of developing both respiratory symptoms and airway hyperresponsiveness.
A B Bohadana; N Massin; P Wild; M N Kolopp; J P Toamain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  7     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-17     Completed Date:  1994-11-17     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1070-6     Citation Subset:  IM    
Institut National de Recherche et Sécurité (INRS), Vandoeuvre-lès-Nancy, France.
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MeSH Terms
Air Pollutants, Occupational / adverse effects*
Cross-Sectional Studies
Dust / adverse effects
Flour / adverse effects*
Linear Models
Logistic Models
Middle Aged
Regression Analysis
Respiratory Function Tests
Respiratory Hypersensitivity / epidemiology*,  etiology*,  physiopathology
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Dust

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