Document Detail

Respiratory symptoms and 30 year mortality from obstructive lung disease and pneumonia.
MedLine Citation:
PMID:  16809414     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: As little is known about the long term relationship between respiratory symptoms and mortality from non-malignant respiratory diseases, a study was undertaken to investigate the predictive value of respiratory symptoms and symptom load for mortality from obstructive lung disease (OLD) and pneumonia in the long term in a Norwegian population. METHODS: In 1972, 19 998 persons aged 15-70 years living in Oslo were randomly selected for a respiratory survey. The response rate was 89%. All were followed for 30 years. The association between cough, asthma-like symptoms, two levels of dyspnoea on exercise, a symptom score, and mortality from OLD and pneumonia were investigated separately for men and women by multivariable analyses, with adjustment for age, occupational exposure to air pollution, and smoking habits. RESULTS: OLD accounted for 43% and pneumonia for 50% of all deaths from respiratory causes. In men the hazard ratio for mortality from OLD varied from 4.0 (95% confidence interval (CI) 2.4 to 6.5) for cough to 9.6 (95% CI 5.1 to 18.3) for severe dyspnoea, and in women from 5.1 (95% CI 2.3 to 11.3) for moderate dyspnoea to 13.0 (95% CI 6.0 to 28.3) for severe dyspnoea. The symptom score was strongly predictive of death from OLD in a dose-response manner. CONCLUSIONS: There is a significant, positive, strong association between respiratory symptoms and 30 year mortality from OLD. The association between respiratory symptoms and mortality from pneumonia is weaker and not significant.
A Frostad; V Soyseth; T Haldorsen; A Andersen; A Gulsvik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-29
Journal Detail:
Title:  Thorax     Volume:  61     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2006-12-19     Revised Date:  2010-09-14    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  951-6     Citation Subset:  IM    
Cancer Registry of Norway, Montebello, N-0310 Oslo, Norway.
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MeSH Terms
Age Distribution
Cause of Death
Cohort Studies
Cross-Sectional Studies
Health Surveys
Lung Diseases, Obstructive / etiology,  mortality*
Middle Aged
Multivariate Analysis
Norway / epidemiology
Pneumonia / etiology,  mortality*
Predictive Value of Tests
Respiration Disorders / complications,  mortality*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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