Document Detail

Respiratory sinus arrhythmia: opposite effects on systolic and mean arterial pressure in supine humans.
MedLine Citation:
PMID:  11579173     Owner:  NLM     Status:  MEDLINE    
1. Are arterial blood pressure fluctuations buffered or reinforced by respiratory sinus arrhythmia (RSA)? There is still considerable debate about this simple question. Different results have been obtained, triggering a discussion as to whether or not the baroreflexes are responsible for RSA. We suspected that the measurements of different aspects of arterial pressure (mean arterial pressure (MAP) and systolic pressure (SP)) can explain the conflicting results. 2. Simultaneous recordings of beat-to-beat MAP, SP, left cardiac stroke volume (SV, pulsed ultrasound Doppler), heart rate (HR) and respiration (RE) were obtained in 10 healthy young adults during spontaneous respiration. In order to eliminate HR variations at respiratory frequency we used propranolol and atropine administration in the supine and tilted positions. Respiration-synchronous variation in the recorded variables was quantified by spectral analysis of the recordings of each of these variables, and the phase relations between them were determined by cross-spectral analysis. 3. MAP fluctuations increased after removing heart rate variations in both supine and tilted position, whereas SP fluctuations decreased in the supine position and increased in the head-up tilted position. 4. RSA buffers respiration-synchronous fluctuations in MAP in both positions. However, fluctuations in SP were reinforced by RSA in the supine and buffered in the tilted position.
M Elstad; K Toska; K H Chon; E A Raeder; R J Cohen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  536     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-01     Completed Date:  2001-12-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  251-9     Citation Subset:  IM; S    
Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103 Blindern, N-0317 Oslo, Norway.
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage
Arrhythmia, Sinus / physiopathology*
Atropine / administration & dosage
Blood Pressure / physiology*
Heart Rate / drug effects,  physiology
Propranolol / administration & dosage
Stroke Volume / physiology
Supine Position
Tilt-Table Test
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 51-55-8/Atropine; 525-66-6/Propranolol
R J Cohen / MIT, Cambridge

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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