Document Detail

Respiratory sinus arrhythmia and central respiratory drive in humans.
MedLine Citation:
PMID:  8777829     Owner:  NLM     Status:  MEDLINE    
1. The influence of central inspiratory drive on heart rate variability was investigated in young human subjects using power spectral analysis of R-R intervals. 2. The area of the high-frequency component occurring at the respiratory frequency (0.2-0.25 Hz) in the power spectral density curves was used as an index of respiratory sinus arrhythmia. 3. Central inspiratory drive was increased by breathing a CO2-enriched (5%) gas mixture and this condition was compared with a similar degree of ventilation produced voluntarily. 4. Tests were conducted on eight young subjects with and without low-dose scopolamine (scopoderm TTS) in a double-blind cross-over trial. 5. Scopolamine decreased heart rate and increased the high-frequency peak, suggesting that its main action on the cardiac vagal pathway was a peripheral one, possibly increasing the efficacy of vagal impulses on the cardiac pacemaker. 6. With scopolamine, CO2 breathing increased the area of the high-frequency component significantly more than a similar degree of ventilatory movements produced by voluntary hyperventilation. 7. It is concluded that respiratory sinus arrhythmia in humans is at least partly dependent on a central respiratory-cardiac coupling, most probably similar to that shown in animal studies.
M Al-Ani; A S Forkins; J N Townend; J H Coote
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  90     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  235-41     Citation Subset:  IM    
Department of Physiology, University of Birmingham, U.K.
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MeSH Terms
Administration, Inhalation
Arrhythmia, Sinus / physiopathology*
Carbon Dioxide / administration & dosage
Heart Rate / drug effects
Hyperventilation / physiopathology
Image Processing, Computer-Assisted
Parasympathetic Nervous System / physiopathology*
Parasympatholytics / pharmacology
Respiration / physiology*
Scopolamine / pharmacology
Reg. No./Substance:
0/Parasympatholytics; 124-38-9/Carbon Dioxide; 51-34-3/Scopolamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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