Document Detail


Respiratory sensations in subjects who lack a ventilatory response to CO2.
MedLine Citation:
PMID:  8210759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An urge to breath is perceived during breath hold and hypercapnia (termed 'air hunger') and during heavy exercise (often termed 'shortness of breath'). To better understand the neural mechanisms responsible for these sensations we studied five patients (8-17 years old) with congenital central hypoventilation syndrome (CCHS) who lack ventilatory response to CO2. CCHS patients reported no respiratory discomfort during CO2 inhalation or during maximal breath hold which was of much longer duration than age-matched controls. However, all 3 CCHS patients who exercised heavily reported some sensations akin to shortness of breath (they increased breathing nearly as much as controls). Our results are consistent with two possibilities. First, the air hunger of hypercapnia and breath hold is caused by projection to the forebrain of respiratory chemoreceptor afferents which bypass the respiratory centers, while exercise shortness of breath is caused by direct projections of limb afferents or locomotory center activity. Second, air hunger and shortness of breath share the same origin--projection of increased brain stem respiratory center motor activity (corollary discharge) to the forebrain.
Authors:
S A Shea; L P Andres; D C Shannon; A Guz; R B Banzett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  93     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-08     Completed Date:  1993-11-08     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  203-19     Citation Subset:  IM    
Affiliation:
Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Carbon Dioxide / pharmacology*
Chemoreceptor Cells / physiology
Child
Exercise / physiology
Female
Humans
Hypocapnia / physiopathology
Hypoventilation / congenital,  physiopathology*
Male
Respiration / physiology*
Sleep Apnea Syndromes / congenital,  physiopathology*
Time Factors
Grant Support
ID/Acronym/Agency:
HL07118/HL/NHLBI NIH HHS; HL19170/HL/NHLBI NIH HHS; HL46690/HL/NHLBI NIH HHS; //Wellcome Trust
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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