| Respiratory response of humans exposed to low levels of ozone for 6.6 hours. | |
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MedLine Citation:
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PMID: 2039268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence suggests that prolonged exposures of exercising men to 0.08 ppm ozone (O3) result in significant decrements in lung function, induction of respiratory symptoms, and increases in nonspecific airway reactivity. The purpose of this study was to confirm or refute these findings by exposing 38 healthy young men to 0.08 ppm O3 for 6.6 h. During exposure, subjects performed exercise for a total of 5 h, which required a minute ventilation of 40 l/min. Significant O3-induced decrements were observed for forced vital capacity (FVC, -0.25 l), forced expiratory volume in 1 s (FEV1.0, -0.35 l), and mean expiratory flow rate between 25% and 75% of FVC (FEF25-75, -0.57 l/s), and significant increases were observed in airway reactivity (35%), specific airway resistance (0.77 cm H2O/s), and respiratory symptoms. These results essentially confirm previous findings. A large range in individual responses was noted (e.g., percentage change in FEV1.0; 4% increase to 38% decrease). Responses also appeared to be nonlinear in time under these experimental conditions. |
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Authors:
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W F McDonnell; H R Kehrl; S Abdul-Salaam; P J Ives; L J Folinsbee; R B Devlin; J J O'Neil; D H Horstman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Archives of environmental health Volume: 46 ISSN: 0003-9896 ISO Abbreviation: Arch. Environ. Health Publication Date: 1991 May-Jun |
Date Detail:
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Created Date: 1991-07-01 Completed Date: 1991-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0212627 Medline TA: Arch Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-50 Citation Subset: AIM; IM |
Affiliation:
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Clinical Research Branch, Environmental Protection Agency, Research Triangle Park, North Carolina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Airway Resistance / drug effects Dose-Response Relationship, Drug Exercise Test* Forced Expiratory Volume / drug effects Humans Male Ozone / toxicity* Respiratory Tract Diseases / chemically induced*, epidemiology, physiopathology Time Factors Vital Capacity / drug effects |
| Chemical | |
Reg. No./Substance:
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10028-15-6/Ozone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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