Document Detail


Respiratory resistance of patients during cardiac stress testing with adenosine: is dyspnea a sign of bronchospasm?
MedLine Citation:
PMID:  18242485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Adenosine is widely used for stress-testing in myocardial perfusion imaging. During adenosine infusion, dyspnea is one of the main complaints of patients. The aim of this study was to determine whether dyspnea during adenosine infusion is caused by bronchospasm. METHODS: Fifty-four patients were enrolled in the study. Seven of these 54 suffered from mild chronic obstructive pulmonary disease (COPD). We continuously measured respiratory resistance (Rrs), using impulse oscillometry. Respiratory resistance was measured before, during, and after a continuous infusion of 140 microg/kg/min adenosine. RESULTS: Sixty-seven percent of patients suffered from dyspnea during adenosine infusion. In patients with mild COPD, Rrs was higher compared with other patients (0.48 vs 0.27 kPa/L/s, P < .05). Neither patients with COPD nor those without COPD exhibited a significant increase in Rrs during adenosine infusion. The Rrs of patients with dyspnea was insignificantly lower compared with patients without dyspnea (P = .469). CONCLUSIONS: Dyspnea as a side effect of adenosine infusion is not correlated with impaired respiratory resistance in nonasthmatic patients and in patients with mild COPD. Thus bronchospasm is ruled out as cause of this clinical symptom. Despite the small number of COPD patients enrolled in the study, adenosine infusion might be possible in patients with mild COPD.
Authors:
Eva Fricke; Elke Esdorn; Annett Kammeier; Harald Fricke; Rainer Preuss; Wolfgang Burchert; Oliver Lindner
Related Documents :
14580925 - Efficacy of the novel phosphodiesterase-4 inhibitor bay 19-8004 on lung function and ai...
10343635 - Cough threshold in patients with chronic obstructive pulmonary disease.
1611335 - Targeting asthma care in general practice using a morbidity index.
19466515 - Effects of chronic obstructive pulmonary disease on coronary atherosclerosis.
24372655 - Evaluation of atrial electromechanical delay and its relationship to inflammation and o...
23287695 - Neurofilament light chain as an early and sensitive predictor of long-term neurological...
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  15     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Affiliation:
Institute of Radiology, Nuclear Medicine, and Molecular Imaging, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany. efricke@hdz-nrw.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenosine / adverse effects*,  diagnostic use
Aged
Airway Resistance / drug effects*
Asthma, Exercise-Induced / etiology*,  radionuclide imaging*
Dyspnea / etiology*,  radionuclide imaging*
Exercise Test / adverse effects,  methods
Female
Humans
Male
Middle Aged
Risk Assessment / methods
Vasodilator Agents / diagnostic use
Ventricular Dysfunction, Left / radionuclide imaging*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 58-61-7/Adenosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of sex, age, and weight on ejection fraction and end-systolic volume reference limits in gate...
Next Document:  Impact of inducible ischemia by stress SPECT in cardiac risk assessment in diabetic patients: ration...