Document Detail

Respiratory resistance of patients during cardiac stress testing with adenosine: is dyspnea a sign of bronchospasm?
MedLine Citation:
PMID:  18242485     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Adenosine is widely used for stress-testing in myocardial perfusion imaging. During adenosine infusion, dyspnea is one of the main complaints of patients. The aim of this study was to determine whether dyspnea during adenosine infusion is caused by bronchospasm. METHODS: Fifty-four patients were enrolled in the study. Seven of these 54 suffered from mild chronic obstructive pulmonary disease (COPD). We continuously measured respiratory resistance (Rrs), using impulse oscillometry. Respiratory resistance was measured before, during, and after a continuous infusion of 140 microg/kg/min adenosine. RESULTS: Sixty-seven percent of patients suffered from dyspnea during adenosine infusion. In patients with mild COPD, Rrs was higher compared with other patients (0.48 vs 0.27 kPa/L/s, P < .05). Neither patients with COPD nor those without COPD exhibited a significant increase in Rrs during adenosine infusion. The Rrs of patients with dyspnea was insignificantly lower compared with patients without dyspnea (P = .469). CONCLUSIONS: Dyspnea as a side effect of adenosine infusion is not correlated with impaired respiratory resistance in nonasthmatic patients and in patients with mild COPD. Thus bronchospasm is ruled out as cause of this clinical symptom. Despite the small number of COPD patients enrolled in the study, adenosine infusion might be possible in patients with mild COPD.
Eva Fricke; Elke Esdorn; Annett Kammeier; Harald Fricke; Rainer Preuss; Wolfgang Burchert; Oliver Lindner
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  15     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-02-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Institute of Radiology, Nuclear Medicine, and Molecular Imaging, Heart and Diabetes Center North Rhine-Westphalia, Bad Oeynhausen, Germany.
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MeSH Terms
Adenosine / adverse effects*,  diagnostic use
Airway Resistance / drug effects*
Asthma, Exercise-Induced / etiology*,  radionuclide imaging*
Dyspnea / etiology*,  radionuclide imaging*
Exercise Test / adverse effects,  methods
Middle Aged
Risk Assessment / methods
Vasodilator Agents / diagnostic use
Ventricular Dysfunction, Left / radionuclide imaging*
Reg. No./Substance:
0/Vasodilator Agents; 58-61-7/Adenosine

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