Document Detail

Respiratory patterns during progressive asphyxia in newborn rabbits.
MedLine Citation:
PMID:  914718     Owner:  NLM     Status:  MEDLINE    
During acute progressive asphyxia an abrupt transition occurs from regular respiratory efforts to primary apnea and gasping. To study this transition we measured inspiratory duration (TI), expiratory duration (TE), maximal inspiratory tracheal pressure (Pmax), electromyographic activity (EMG) of different muscle groups, and the electrocorticogram (ECoG) of 3- to 5-day-old rabbits following airway occlusion at functional residual capacity (FRC). The onset of primary apnea was associated with other central nervous system events as indicated by decerebrate posture and maximal EMG activity which were followed by relaxation, loss of EMG activity, and an isoelectric ECoG. Indices of inspiratory drive (Pmax and Pmax/TI) were preserved or accentuated following primary apnea despite a reduction of overall respiratory activity (frequency X Pmax). The onset of primary apnea appears to be due to interruption of the respiratory cycling controls rather than failure of the respiratory center which regulates inspiratory force. Gasping appears to be linked with progressive changes in respiratory patterns which are observed prior to primary apnea. These findings do not support the concept of a "gasping" center.
E E Lawson; B T Thach
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  43     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  468-74     Citation Subset:  IM    
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MeSH Terms
Airway Obstruction
Animals, Newborn*
Asphyxia / physiopathology*
Decerebrate State / physiopathology
Functional Residual Capacity
Lung / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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