Document Detail

Respiratory pathophysiology of panic disorder: an ambulatory monitoring study.
MedLine Citation:
PMID:  19737858     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the external validity of laboratory baselines in panic disorder (PD), frequently associated with respiratory pattern abnormalities like increased respiratory variability and sighing, implying a stable pathophysiologic trait characteristic. METHODS: Physical activity and a variety of breath-by-breath volumetric, timing, and variability measures of respiration were recorded in the daily life of 26 patients with PD and 26 healthy controls (HC), using a novel ambulatory monitoring system optimized for reliable assessment of respiratory pattern. Data were stratified for physical activity to eliminate its confounding effects. RESULTS: Groups showed strong and consistent diurnal patterns in almost all respiratory variables. However, patients with PD did not differ from HC regarding any of the respiratory timing, volumetric and variability measures, with negligible group effect sizes for all measures. Patients with fewer self-reported respiratory symptoms of anxiety exhibited more pronounced rapid shallow breathing as well as diminished total breath time and its variability. CONCLUSIONS: Despite state-of-the-art ambulatory assessment and sufficient statistical power to detect respiratory alterations previously observed in the laboratory, we found no evidence for such alterations in PD patients' daily life. Neither the total PD group nor patients with particularly pronounced respiratory symptomatology displayed increased respiratory variability. These results caution against interpreting results from laboratory baselines in PD as reflecting a stable trait characteristic. Rather, they likely represent a state-trait interaction due to enhanced reactivity of PD patients to novel environments. These results challenge aspects of respiratory theories of PD that were based on laboratory findings.
Monique C Pfaltz; Tanja Michael; Paul Grossman; Jens Blechert; Frank H Wilhelm
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-08
Journal Detail:
Title:  Psychosomatic medicine     Volume:  71     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-15     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  869-76     Citation Subset:  IM    
Faculty of Psychology, Department of Clinical Psychology and Psychotherapy, University of Basel, CH-4055 Basel, Switzerland.
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MeSH Terms
Activities of Daily Living
Anxiety Disorders / diagnosis,  physiopathology
Biological Markers
Circadian Rhythm / physiology
Combat Disorders / physiopathology
Data Collection / statistics & numerical data
Monitoring, Ambulatory / methods,  statistics & numerical data*
Motor Activity / physiology
Panic Disorder / diagnosis,  physiopathology*
Personality Inventory
Reproducibility of Results
Respiration Disorders / diagnosis,  physiopathology
Respiratory Function Tests / methods,  statistics & numerical data*
Respiratory System / physiopathology*
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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