Document Detail

Respiratory outcomes in early childhood following antenatal vitamin C and E supplementation.
MedLine Citation:
PMID:  20889523     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Prenatal antioxidant supplementation might influence fetal lung growth and development and reduce infant respiratory morbidity. The aim of this study was to test the hypothesis that infants of mothers at risk of pre-eclampsia who were randomised to receive high-dose vitamins C and E (1000 mg vitamin C and 400 IU RRR α-tocopherol daily) during pregnancy would have better respiratory outcomes than infants whose mothers were randomised to receive placebo.
METHODS: Respiratory outcomes to 2 years of age were documented using questionnaires and, in a subset, by recording their healthcare utilisation and calculating the cost of care data.
RESULTS: 330 women who had taken vitamin supplementation and 313 who had taken placebo completed the respiratory questionnaire (386 and 366 infants, respectively). There were no significant differences between the two groups in the proportions diagnosed with asthma. 54 women who had taken vitamin supplementation and 45 who had taken placebo took part in the healthcare utilisation study (65 and 53 infants, respectively). On average, infants of mothers receiving vitamin supplementation had 2.6 (99% CI 0.8 to 5.1) times more A&E/outpatient visits and 3.2 (99% CI 0.2 to 6.9) times more GP visits than infants of mothers receiving placebo, and their costs of care were £226 (99% CI £27 to £488) more for outpatient admissions, £57 (99% CI £3 to £123) more for GP visits and £22 (99% CI £3 to £50) more for medications.
CONCLUSIONS: High-dose antenatal vitamin C and E supplementation does not improve infant respiratory outcome and is associated with increased healthcare utilisation and cost of care.
Anne Greenough; Seif O Shaheen; Andrew Shennan; Paul T Seed; Lucilla Poston
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-10-01
Journal Detail:
Title:  Thorax     Volume:  65     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  998-1003     Citation Subset:  IM    
Division of Asthma, Allergy and Lung Biology, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.
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MeSH Terms
Antioxidants / administration & dosage,  therapeutic use*
Ascorbic Acid / administration & dosage,  therapeutic use*
Birth Weight
Child Health Services / economics
Dietary Supplements
Drug Administration Schedule
Health Care Costs / statistics & numerical data
Health Services / utilization
Infant, Newborn
Infant, Premature
Pre-Eclampsia / prevention & control
Pregnancy Outcome
Prenatal Care / methods*
Respiration Disorders / economics,  embryology,  prevention & control*
Risk Factors
Treatment Outcome
Vitamin E / administration & dosage,  therapeutic use*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid

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