| Respiratory outcome in preterm small for gestational age fetuses with or without abnormal umbilical artery Doppler and/or maternal hypertension. | |
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MedLine Citation:
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PMID: 17674279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study respiratory outcome in preterm small for gestational age (SGA) fetuses with or without signs of intrauterine growth restriction due to placental insufficiency, and with or without maternal hypertension. METHODS: This was a retrospective study of 187 neonates with birth weight <10(th) percentile and gestational age <34 weeks. Results from umbilical artery Doppler velocimetry were used to identify the abnormal Doppler subgroup. RESULTS: No significant difference in respiratory outcome between SGA fetuses with normal (SGA-N) or abnormal (SGA-A) umbilical artery Doppler examination was found. Within the SGA-A group, the respiratory distress syndrome (RDS) incidence (OR 5.6, 95% CI 1.7-18.3), RDS grade (OR 6.7, 95% CI 1.2-38.5), and need for surfactant (OR 5.3, 95% CI 1.1-24.4) were higher in infants of women with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome as compared to those of normotensive mothers. CONCLUSIONS: Lung maturation is not accelerated with placental insufficiency. SGA-A fetuses of mothers with HELLP syndrome have a significantly poorer respiratory outcome than those with healthy mothers. Possibly, fetuses of mothers with HELLP syndrome are subjected to 'oxidative stress' causing lung damage rather than lung maturation. |
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Authors:
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Helen L Torrance; Eduard J H Mulder; Hens A A Brouwers; Frank van Bel; Gerard H A Visser |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 20 ISSN: 1476-7058 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-03 Completed Date: 2007-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: United States |
Other Details:
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Languages: eng Pagination: 613-21 Citation Subset: IM |
Affiliation:
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Perinatal Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. H.Torrance@umcutrecht.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity
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physiology Drug Utilization Female Glucocorticoids / therapeutic use HELLP Syndrome / physiopathology* Humans Infant Mortality Infant, Newborn Infant, Premature* Infant, Small for Gestational Age* Male Outcome Assessment (Health Care)* Pregnancy Pulmonary Surfactants / therapeutic use Respiration, Artificial Respiratory Distress Syndrome, Newborn / physiopathology*, therapy Retrospective Studies Severity of Illness Index Ultrasonography, Doppler Umbilical Arteries / ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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