| Respiratory muscle strength and the risk of incident cardiovascular events. | |
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MedLine Citation:
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PMID: 15563706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Maximal inspiratory pressure (MIP) is a measure of inspiratory muscle strength. The prognostic importance of MIP for cardiovascular events among elderly community dwelling individuals is unknown. Diminished forced vital capacity (FVC) is a risk factor for cardiovascular events which remains largely unexplained. METHODS: MIP was measured at the baseline examination of the Cardiovascular Health Study. Participants had to be free of prevalent congestive heart failure (CHF), myocardial infarction (MI), and stroke. RESULTS: Subjects in the lowest quintile of MIP had a 1.5-fold increased risk of MI (HR 1.48, 95% CI 1.07 to 2.06) and cardiovascular disease (CVD) death (HR 1.54, 95% CI 1.09 to 2.15) after adjustment for non-pulmonary function covariates. There was a potential inverse relationship with stroke (HR 1.36, 95% CI 0.97 to 1.90), but there was little evidence of an association between MIP and CHF (HR 1.22, 95% CI 0.93 to 1.60). The addition of FVC to models attenuated the HR associated with MIP only modestly; similarly, addition of MIP attenuated the HR associated with FVC only modestly. CONCLUSIONS: A reduced MIP is an independent risk factor for MI and CVD death, and a suggestion of an increased risk for stroke. This association with MIP appeared to be mediated through mechanisms other than inflammation. |
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Authors:
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J van der Palen; T D Rea; T A Manolio; T Lumley; A B Newman; R P Tracy; P L Enright; B M Psaty |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Thorax Volume: 59 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-25 Completed Date: 2004-12-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 1063-7 Citation Subset: IM |
Affiliation:
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Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA. vdpalen@euronet.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiovascular Diseases
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etiology*,
physiopathology Female Follow-Up Studies Forced Expiratory Volume / physiology Humans Male Maximal Voluntary Ventilation / physiology Prospective Studies Respiratory Muscles / physiology* Risk Factors Vital Capacity / physiology |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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