Document Detail


Respiratory muscle blood flow in exercising dogs after pneumonectomy.
MedLine Citation:
PMID:  1506376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In three foxhounds after left pneumonectomy, the relationships of ventilatory work and respiratory muscle (RM) blood flow to ventilation (VE) during steady-state exercise were examined. VE was measured using a specially constructed respiratory mask and a pneumotach; work of breathing was measured by the esophageal balloon technique. Blood flow to RM was measured by the radionuclide-labeled microsphere technique. Lung compliance after pneumonectomy was 55% of that before pneumonectomy; compliance of the thorax was unchanged. O2 uptake (VO2) of RM comprised only 5% of total body VO2 at exercise. At rest, inspiratory muscles received 62% and expiratory muscles 38% of the total O2 delivered to the RM (QO2RM). During exercise, inspiratory muscles received 59% and expiratory muscles 41% of total QO2RM. Blood flow per gram of muscle to the costal diaphragm was significantly higher than that to the crural diaphragm. The diaphragm, parasternals, and posterior cricoarytenoids were the most important inspiratory muscles, and internal intercostals and external obliques were the most important expiratory muscles for exercise. Up to a VE of 120 l/min through one lung, QO2RM constituted only a small fraction of total body VO2 during exercise and maximal vasodilation in the diaphragm was never approached.
Authors:
C C Hsia; M Ramanathan; J L Pean; R L Johnson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  73     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-21     Completed Date:  1992-09-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-7     Citation Subset:  IM; S    
Affiliation:
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Female
Hemodynamics / physiology
Lung Compliance / physiology
Microspheres
Oxygen Consumption / physiology
Physical Exertion / physiology*
Pneumonectomy*
Regional Blood Flow / physiology
Respiratory Mechanics / physiology
Respiratory Muscles / blood supply*
Work of Breathing / physiology
Grant Support
ID/Acronym/Agency:
HL-07362/HL/NHLBI NIH HHS; HL-40070/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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