Document Detail


Respiratory muscle activity related to flow and lung volume in preterm infants compared with term infants.
MedLine Citation:
PMID:  20606599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infants with chronic lung disease (CLD) have a capacity to maintain functional lung volume despite alterations to their lung mechanics. We hypothesize that they achieve this by altering breathing patterns and dynamic elevation of lung volume, leading to differences in the relationship between respiratory muscle activity, flow and lung volume. Lung function and transcutaneous electromyography of the respiratory muscles (rEMG) were measured in 20 infants with CLD and in 39 healthy age-matched controls during quiet sleep. We compared coefficient of variations (CVs) of rEMG and the temporal relationship of rEMG variables, to flow and lung volume [functional residual capacity (FRC)] between these groups. The time between the start of inspiratory muscle activity and the resulting flow (tria)--in relation to respiratory cycle time--was significantly longer in infants with CLD. Although FRC had similar associations with tria and postinspiratory activity (corrected for respiratory cycle time), the CV of the diaphragmatic rEMG was lower in CLD infants (22.6 versus 31.0%, p = 0.030). The temporal relationship of rEMG to flow and FRC and the loss of adaptive variability provide additional information on coping mechanisms in infants with CLD. This technique could be used for noninvasive bedside monitoring of CLD.
Authors:
Gerard J Hutten; Leo A van Eykern; Philipp Latzin; Cindy Thamrin; Wim M van Aalderen; Urs Frey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-43     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Inselspital, University of Bern, Bern 3010, Switzerland. g.j.hutten@amc.uva.nl
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Case-Control Studies
Chronic Disease
Electromyography
Functional Residual Capacity
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / physiopathology*
Lung / physiopathology*
Lung Diseases / physiopathology*
Lung Volume Measurements
Respiratory Mechanics
Respiratory Muscles / physiopathology*
Tidal Volume
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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