| Respiratory motion-compensated radial dynamic contrast-enhanced (DCE)-MRI of chest and abdominal lesions. | |
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MedLine Citation:
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PMID: 18956465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced (DCE)-MRI is becoming an increasingly important tool for evaluating tumor vascularity and assessing the effectiveness of emerging antiangiogenic and antivascular agents. In chest and abdominal regions, however, respiratory motion can seriously degrade the achievable image quality in DCE-MRI studies. The purpose of this work is to develop a respiratory motion-compensated DCE-MRI technique that combines the self-gating properties of radial imaging with the reconstruction flexibility afforded by the golden-angle view-order strategy. Following radial data acquisition, the signal at k-space center is first used to determine the respiratory cycle, and consecutive views during the expiratory phase of each respiratory period (34-55 views, depending on the breathing rate) are grouped into individual segments. Residual intrasegment translation of lesion is subsequently compensated for by an autofocusing technique that optimizes image entropy, while intersegment translation (among different respiratory cycles) is corrected using 3D image correlation. The resulting motion-compensated, undersampled dynamic image series is then processed to reduce image streaking and to enhance the signal-to-noise ratio (SNR) prior to perfusion analysis, using either the k-space-weighted image contrast (KWIC) radial filtering technique or principal component analysis (PCA). The proposed data acquisition scheme also allows for high frame-rate arterial input function (AIF) sampling and free-breathing baseline T(1) mapping. The performance of the proposed radial DCE-MRI technique is evaluated in subjects with lung and liver lesions, and results demonstrate that excellent pixelwise perfusion maps can be obtained with the proposed methodology. |
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Authors:
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Wei Lin; Junyu Guo; Mark A Rosen; Hee Kwon Song |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 60 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2009-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1135-46 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA. weilin@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Neoplasms
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diagnosis* Algorithms Artifacts* Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging / methods* Reproducibility of Results Respiratory Mechanics* Respiratory-Gated Imaging Techniques / methods* Sensitivity and Specificity Thoracic Neoplasms / diagnosis* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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