Document Detail

Respiratory and metabolic responses of fetal and neonatal perfused livers to catecholamines and anoxia.
MedLine Citation:
PMID:  3385281     Owner:  NLM     Status:  MEDLINE    
The effects of catecholamine and anoxia on the respiratory and metabolic function of developing livers were studied. The characteristic feature of the fetal liver was catecholamine induced glycolysis, although that of the neonatal liver was gluconeogenesis. Infusion of lactate and pyruvate caused a reduction in NAD in the fetus and adult, and NAD oxidation in the newborn. The fetal liver demonstrated marked tolerance of anoxic load, but the tolerance was rapidly lost after birth. The metabolic response to catecholamine may be mediated by the alpha-adrenergic receptor rather than the beta-receptor.
T Kaneoka; S Taguchi; H Shimizu; K Shirakawa
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nihon Sanka Fujinka Gakkai zasshi     Volume:  40     ISSN:  0300-9165     ISO Abbreviation:  Nippon Sanka Fujinka Gakkai Zasshi     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-08-11     Completed Date:  1988-08-11     Revised Date:  2011-07-29    
Medline Journal Info:
Nlm Unique ID:  7505749     Medline TA:  Nihon Sanka Fujinka Gakkai Zasshi     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  627-34     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Fukuoka University School of Medicine.
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MeSH Terms
Animals, Newborn / metabolism
Gluconeogenesis / drug effects
Glycolysis / drug effects
Guinea Pigs
Lactates / pharmacology
Lactic Acid
Liver / drug effects,  embryology,  metabolism*
NAD / metabolism
Norepinephrine / pharmacology*
Oxidation-Reduction / drug effects
Oxygen Consumption / drug effects*
Pyruvates / pharmacology
Pyruvic Acid
Reg. No./Substance:
0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 51-41-2/Norepinephrine; 53-84-9/NAD

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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