| Respiratory and metabolic response of rats and mice to formalin vapor. | |
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MedLine Citation:
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PMID: 6818719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The irritant effect of repeated inhalation exposure to vapors of aqueous formalin (formaldehyde concentration, 15 ppm) in male Charles River CD rats and male C57BL6/F1 mice was determined. The data suggest that rats are relatively insensitive to this irritant while mice are substantially more sensitive, the latter showing a comparable reduction in tidal volume, but a greater decrease in respiratory rate and, as a consequence, minute volume. CO2 production, a reflection of total metabolism, as well as body temperature, were decreased to a greater extent in mice than in rats. The decreased minute ventilation and associated decrease in temperature, responses occurring to a greater extent in the mouse, may decrease both the net formaldehyde dose as well as the toxic actions of formaldehyde that are dependent on systemic metabolic activity. |
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Authors:
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R J Jaeger; J M Gearhart |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Toxicology Volume: 25 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1982 |
Date Detail:
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Created Date: 1983-03-24 Completed Date: 1983-03-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 299-309 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / metabolism Formaldehyde / toxicity* Gases Male Metabolism / drug effects* Mice Mice, Inbred C57BL Rats Respiration / drug effects* Restraint, Physical Species Specificity Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA 26724/CA/NCI NIH HHS; CA 33243/CA/NCI NIH HHS; ES 00264/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gases; 124-38-9/Carbon Dioxide; 50-00-0/Formaldehyde |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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