| Respiratory mechanics in COPD patients who failed non-invasive ventilation: Role of intrinsic PEEP. | |
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MedLine Citation:
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PMID: 22877584 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Non-invasive positive pressure ventilation (NPPV) is the first choice to treat exacerbations in COPD patients. NPPV can fail owing to different causes related to gas exchange impairment (RF group) or intolerance (INT group). To assess if the respiratory mechanical properties and the ratio between the dynamic and static intrinsic positive end-expiratory pressure (PEEP(i),dyn/PEEP(i),stat), reflecting lung mechanical inequalities, were different between groups, 29 COPD patients who failed NPPV (15 RF and 14 INT) were studied, early after the application of invasive ventilation. Blood gas analysis, clinical status, and mechanical properties were measured. pH was higher in INT patients before intubation (p<0.001). PEEP(i),dyn/PEEP(i),stat was found higher in INT group with (p=0.021) and without PEEP (ZEEP, p<0.01). PEEP(i),dyn/PEEP(i),stat was exponentially associated with the duration of NPPV in INT group (p=0.011). INT and RF patients had similar impairment of respiratory system resistance and elastance. |
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Authors:
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Vittorio Antonaglia; Massimo Ferluga; Guido Capitanio; Umberto Lucangelo; Fulvia Piller; Erik Roman-Pognuz; Bruno Biancardi; Giuseppe Davide Caggegi; Walter A Zin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-2 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Anesthesia and Intensive Care, Laboratory of Respiratory Biomechanics, University of Trieste, Cattinara Hospital, Trieste, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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