Document Detail

Respiratory load-compensating mechanisms in muscular dystrophy.
MedLine Citation:
PMID:  3597236     Owner:  NLM     Status:  MEDLINE    
First-breath ventilatory responses to graded elastic and resistive loads were obtained from 15 people with Duchenne muscular dystrophy (DMD), 5 people with facioscapulohumeral MD (FSH), 3 people with Becker MD, and 3 people with limb-girdle MD. For each load tidal volumes from different individuals ranged from relatively small to comparatively large values, indicating a correspondingly wide range of end-inspiratory efforts; strong tidal volume defenders generally employed longer inspirations and higher mean inspiratory airflows than did weak tidal volume defenders; and individual frequency responses were mediated by changes in inspiratory and/or expiratory timing. Thus the loaded breathing responses of people with MD are qualitatively the same as those of quadriplegic and able-bodied people. Quantitatively, however, the DMD group generated considerably larger tidal volumes than did the FSH group during both elastic and resistive loading. These larger tidal volumes were achieved by both longer inspirations (a neurally mediated phenomenon) and higher mean inspiratory airflows (a mechanically and/or neurally mediated phenomenon). These findings, which could not be attributed to differences in respiratory motor function, suggest that there are differences between the respiratory sensory and/or central functions in the Duchenne and facioscapulohumeral types of MD.
K Axen; M Bishop; F Haas
Related Documents :
2064116 - Expiratory muscle recruitment during inspiratory flow-resistive loading and exercise.
11991876 - Effect of severe isolated unilateral and bilateral diaphragm weakness on exercise perfo...
3159716 - Effects of separate rib cage and abdominal restriction on exercise performance in norma...
7836106 - Cerebellar modulation of ventilatory response to progressive hypercapnia.
2632736 - Hypertension and cardiac complications in normotensive myocardial infarction patients w...
18708146 - Deletion of lysophosphatidic acid receptor lpa1 reduces neurogenesis in the mouse denta...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  62     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-07-24     Completed Date:  1987-07-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1647-54     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Muscular Dystrophies / classification,  physiopathology*
Pulmonary Ventilation
Tidal Volume
Time Factors
Work of Breathing*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Opposing effects of anesthetics on pressure tolerance and compression rate effect.
Next Document:  Effect of hyperinflation and equalization of abdominal pressure on diaphragmatic action.