Document Detail


Respiratory irritation associated with inhalation of boron trifluoride and fluorosulfonic acid.
MedLine Citation:
PMID:  18464054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objectives of this study were to examine the respiratory irritancy of boron trifluoride (BF(3)) and fluorosulfonic acid (FSA) following acute inhalation exposure. Testing was conducted using groups of 10 male and 10 female rats (BF(3)) or groups of 6 male rats (FSA). Rats were exposed for a single 4-h period (BF(3)) or a single 1-h period (FSA) and necropsied 1 or 14 days after exposure (BF(3)) or 14 days after exposure (FSA). Measurements consisted of clinical signs, body weight, kidney and lung weight, histopathology (BF(3)), and breathing parameters (FSA) and were used to evaluate the possible irritating effects of these compounds. The results indicated treatment-related findings in the larynx and trachea in the rats exposed to 74.4 mg/m(3) BF(3), consisting of ventral cartilage necrosis, hemorrhage, and an increase in ventral epithelial hyperplasia and ventral inflammatory cell inflammation 24 h postexposure. In the animals sacrificed 14 days postexposure, the only notable observation was ventral cartilage necrosis, present in 2 animals. The next lower level tested, 24.6 mg/m(3) BF, was considered a no-observed-adverse-effects level (NOAEL). A concentration of 4125 mg/m(3) FSA resulted in a clearly decreased breathing rate during and shortly after exposure with 67% (4/6) mortality on days 5-9 after exposure. A concentration of 845 mg/m(3) FSA resulted in only minor signs of irritation, consisting of slight changes in breathing pattern shorlty after exposure. The results of the present 4-h inhalation study with BF(3) indicated that respiratory irritation was present at a level of 74.4 mg/m(3) whereas 24.6 mg/m(3) was a NOAEL. A single 1-h exposure to 845 mg/m(3) FSA resulted in only minor signs of respiratory irritation, indicating that on a mass basis FSA is no more toxic or irritating than hydrogen fluoride (HF) or sulfuric acid.
Authors:
George M Rusch; Anthony M Bowden; Hans Muijser; Josje Arts
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  20     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-08     Completed Date:  2008-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  665-70     Citation Subset:  IM    
Affiliation:
Honeywell International, Morristown, New Jersey 07960, USA. george.rusch@honeywell.com
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MeSH Terms
Descriptor/Qualifier:
Acute Toxicity Tests
Animals
Boranes / toxicity*
Female
Fluorides / toxicity*
Irritants / toxicity*
Male
Rats
Rats, Sprague-Dawley
Respiratory Mechanics / drug effects
Respiratory Tract Diseases / chemically induced*,  pathology
Sulfuric Acids / toxicity*
Chemical
Reg. No./Substance:
0/Boranes; 0/Fluorides; 0/Irritants; 0/Sulfuric Acids; 7637-07-2/boron trifluoride; 7789-21-1/fluorosulfonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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