| Respiratory involvement in systemic lupus erythematosus. | |
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MedLine Citation:
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PMID: 20965395 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Respiratory involvement in systemic lupus erythematosus (SLE) is not as well-known as the cutaneous, rheumatological and renal manifestations. It occurs frequently but the diagnosis may be difficult because of the heterogeneity of the anatomical and clinical presentations. A precise diagnosis is crucial as new immunosuppressive drugs have considerably improved the prognosis. The pathology involves genetic, endocrine, environmental, pharmacological and immunological factors with a cytotoxic reaction of auto-antibodies against complement, a circulating immune complex reaction and a hyperactivity of B lymphocytes. Respiratory involvement in SLE can be classified in five groups based on the anatomy: pleural involvement, infiltrating pneumonia (lymphoid interstitial pneumonia, bronchiolitis obliterans with organizing pneumonia and acute lupus pneumonitis), airways involvement (upper airways, bronchi), vascular involvement (pulmonary hypertension, acute reversible hypoxaemia, alveolar haemorrhage, and antiphospholipid syndrome), muscular and diaphragmatic involvement (shrinking lung syndrome).Treatment is based, depending upon the type of involvement and its severity, on steroids which may be combined with immunosuppressants and plasmapherisis. |
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Authors:
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D Carmier; S Marchand-Adam; P Diot; E Diot |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Revue des maladies respiratoires Volume: 27 ISSN: 1776-2588 ISO Abbreviation: Rev Mal Respir Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8408032 Medline TA: Rev Mal Respir Country: France |
Other Details:
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Languages: eng Pagination: e66-78 Citation Subset: IM |
Copyright Information:
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Copyright © 2010. Published by Elsevier Masson SAS. |
Affiliation:
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Service de pneumologie, CHRU François-Rabelais de Tours, université François-Rabelais de Tours, 37044 Tours, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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