| Respiratory impedance during weaning from mechanical ventilation in a mixed population of critically ill patients. | |
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MedLine Citation:
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PMID: 19887532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Worsening of respiratory mechanics during a spontaneous breathing trial (SBT) has been traditionally associated with weaning failure, although this finding is based on studies with chronic obstructive pulmonary disease patients only. The aim of our study was to assess the course of respiratory impedance non-invasively measured by forced oscillation technique (FOT) during a successful and failed SBT in a mixed population. METHODS: Thirty-four weaning trials were reported in 29 consecutive mechanically ventilated patients with different causes of initiation of ventilation. During the SBT, the patient was breathing through a conventional T-piece connected to the tracheal tube. FOT (5 Hz, +/- 1 cm H(2)O, 30 s) was applied at 5, 10, 15, 20, 25, and 30 min. Respiratory resistance (Rrs) and reactance (Xrs) were computed from pressure and flow measurements. The frequency to tidal volume ratio f/V(t) was obtained from the flow signal. At the end of the trial, patients were divided into two groups: SBT success and failure. RESULTS: Mixed model analysis showed no significant differences in Rrs and Xrs over the course of the SBT, or between the success (n=16) and the failure (n=18) groups. In contrast, f/V(t) was significantly (P<0.001) higher in the failure group. CONCLUSIONS: Worsening of respiratory impedance measured by FOT is not a common finding during a failed SBT in a typically heterogeneous intensive care unit population of mechanically ventilated patients. |
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Authors:
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J Sellares; I Acerbi; H Loureiro; R L Dellaca; M Ferrer; A Torres; D Navajas; R Farre |
Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't Date: 2009-11-03 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 103 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 828-32 Citation Subset: IM |
Affiliation:
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Servicio de Neumología, Instituto Clínico del Tórax, Hospital Clínic de Barcelona - Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona (UB), Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Airway Resistance / physiology* Critical Illness / therapy* Female Humans Inhalation / physiology Intensive Care / methods Male Oscillometry / methods Prospective Studies Respiratory Function Tests / methods Tidal Volume Treatment Failure Ventilator Weaning* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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