Document Detail

Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine.
MedLine Citation:
PMID:  164502     Owner:  NLM     Status:  MEDLINE    
Animal experiments have shown that respiratory administration of pertussis antigen induces a protective immune response. In this study pertussis antibody in human respiratory secretions was measured and the response to aerosol and intramuscular pertussis immunization investigated. Substanial increases in this antibody occurred after aerosol immunization but no changes were found in serum antibody. The reverse was observed after intramuscular pertussis vaccine in adults but not with aerosol immunization. The latter method may be of value for paediatric medical and nursing personnel exposed to the risk of pertussis infection.
G Thomas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of hygiene     Volume:  74     ISSN:  0022-1724     ISO Abbreviation:  J Hyg (Lond)     Publication Date:  1975 Apr 
Date Detail:
Created Date:  1975-06-18     Completed Date:  1975-06-18     Revised Date:  2010-09-01    
Medline Journal Info:
Nlm Unique ID:  0375374     Medline TA:  J Hyg (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
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MeSH Terms
Antibodies, Bacterial / analysis*
Antibody Formation*
Bordetella pertussis / immunology*
Hemagglutination Tests
Immunoglobulin A / analysis
Injections, Intramuscular*
Nasal Mucosa / immunology,  secretion
Pertussis Vaccine / administration & dosage*
Reg. No./Substance:
0/Aerosols; 0/Antibodies, Bacterial; 0/Immunoglobulin A; 0/Pertussis Vaccine

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