Document Detail

Respiratory function and the obesity paradox.
MedLine Citation:
PMID:  20975350     Owner:  NLM     Status:  In-Process    
PURPOSE OF REVIEW: Obese individuals have impaired respiratory function relative to their normal-weight counterparts. Despite these negative effects, obesity is paradoxically associated with better survival in individuals with chronic obstructive pulmonary disease (COPD). The purpose of this review is to describe this 'obesity paradox', to discuss the effects of obesity on respiratory function, and to speculate as to whether obesity-related alterations in respiratory mechanics can influence the natural history of COPD.
RECENT FINDINGS: Given the known negative effects of obesity on respiratory physiology, it is reasonable to predict that obese COPD patients would be more likely to experience greater dyspnea and exercise intolerance relative to COPD patients of normal weight. However, recent evidence suggests that obese COPD patients have similar or better dyspnea scores during exercise and do not have diminished exercise capacity. These observations may be attributable to the fact that obese COPD patients have reduced operating lung volumes and higher inspiratory capacity to total lung capacity ratios than their lean COPD counterparts.
SUMMARY: Obese patients with COPD do not appear to be at a disadvantage during exercise relative to lean COPD patients. Obesity may be associated with improved survival in COPD but specific mechanisms for this paradox remain to be elucidated.
Jordan A Guenette; Dennis Jensen; Denis E O'Donnell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  13     ISSN:  1535-3885     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  618-24     Citation Subset:  IM    
Respiratory Investigation Unit, Department of Medicine, Queen's University, Kingston General Hospital, Kingston, Ontario, Canada.
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