Document Detail

Respiratory failure in the neurological patient: the diagnosis of neurogenic pulmonary edema.
MedLine Citation:
PMID:  11497073     Owner:  NLM     Status:  MEDLINE    
Neurogenic pulmonary edema (NPE) is a potential complication of a central nervous system (CNS) insult such as intracranial hemorrhage, uncontrolled generalized seizures, head trauma, tumors, and neurosurgical procedures. The proposed etiology is massive sympathetic discharge following a CNS event. The pathogenesis is not completely understood. However, there are two theories on how NPE occurs: the blast theory and the permeability defect theory. There is evidence for both theories, and NPE is probably the result of a combination of the two. The treatment is mainly supportive with the use of mechanical ventilation and alpha-adrenergic blocking agents while managing increased intracranial pressure. A thorough understanding of the pathophysiological mechanisms behind the development of NPE aids in the management of these patients to prevent further complications.
A M Pyeron
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses     Volume:  33     ISSN:  0888-0395     ISO Abbreviation:  J Neurosci Nurs     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-10     Completed Date:  2001-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8603596     Medline TA:  J Neurosci Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-7     Citation Subset:  IM; N    
Merck & Co, Inc.
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MeSH Terms
Adrenergic alpha-Antagonists / therapeutic use
Central Nervous System Diseases / complications*,  physiopathology,  therapy
Cerebral Hemorrhage / complications*,  physiopathology,  therapy
Combined Modality Therapy
Middle Aged
Nursing Assessment
Patient Care Planning
Postoperative Care
Pulmonary Edema / diagnosis,  etiology*,  physiopathology,  therapy
Respiration, Artificial
Respiratory Insufficiency / diagnosis,  etiology*,  physiopathology,  therapy
Reg. No./Substance:
0/Adrenergic alpha-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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