| Respiratory failure in ANCA-associated vasculitis. | |
| | |
MedLine Citation:
|
PMID: 8697833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the prevalence, clinical manifestations, and course of respiratory failure in all patients who tested positive for antineutrophil cytoplasmic autoantibodies (ANCA) in our clinics in the period between January 1985 and January 1993. DESIGN: Case-series analysis. SETTING: Three teaching hospitals in the Netherlands. PATIENTS: Two hundred twenty consecutive patients suspected of having vasculitis and/or glomerulonephritis who tested positive for ANCA by indirect immunofluorescence and enzyme-linked immunosorbent assay. RESULTS: Sixty-two patients had pulmonary involvement. Acute respiratory failure developed in nine. Respiratory failure was related to infections in two of them and to ANCA-associated vasculitis in seven. These seven patients uniformly presented with pulmonary hemorrhage and diffuse pulmonary infiltrates. The diagnosis of systemic vasculitis was supported by the presence of a pulmonary-renal syndrome in all patients, and by detection of antibodies to the proteinase 3 or myeloperoxidase antigen in all but one patient. Antiglomerular basement membrane antibodies were absent. The mortality was high due to hypoxic respiratory failure, pulmonary superinfections, and concomitant renal failure. CONCLUSIONS: Acute respiratory failure due to vasculitis developed in one of every nine patients with ANCA-associated pulmonary disease. Patients usually present with pulmonary infiltrates and hemoptysis. A diagnosis of vasculitis may be further supported by analysis of the urinary sediment and determination of the ANCA target antigen. It remains to be proved that early detection of ANCA favorably affects the outcome. |
| | |
Authors:
|
J C ter Maaten; C F Franssen; R O Gans; R J van Schijndel; S J Hoorntje |
Related Documents
:
|
15791043 - Oral sildenafil improves primary pulmonary hypertension refractory to epoprostenol. 3568773 - Patients with collagen vascular disease and dyspnea. the value of gallium scanning and ... 944393 - Primary sensory symptoms in parkinsonism. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Chest Volume: 110 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1996 Aug |
Date Detail:
|
Created Date: 1996-09-05 Completed Date: 1996-09-05 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 357-62 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Catharina Hospital, Eindhoven, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Antibodies, Antineutrophil Cytoplasmic Autoantibodies / analysis* Dyspnea / etiology Female Hemoptysis / etiology Humans Immunosuppressive Agents / therapeutic use Male Middle Aged Respiratory Insufficiency / etiology* Vasculitis / complications*, drug therapy, immunology |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Antineutrophil Cytoplasmic; 0/Autoantibodies; 0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chlamydia pneumoniae pneumonia in hospitalized patients. Clinical characteristics and diagnostic val...
Next Document: A 12-year longitudinal study of Aspergillus sensitivity in patients with cystic fibrosis.