| Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia. | |
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MedLine Citation:
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PMID: 6831346 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four patients with acute nonlymphocytic leukemia and leukocyte counts of more than 200,000/mm3 developed respiratory distress due to pulmonary leukostasis within 10-48 hours after initiation of chemotherapy. Clinically, the patients manifested fever, dyspnea, tachypnea, diffuse pulmonary rales, pleural effusions, and severe hypoxemia. Chest roentgenograms displayed diffuse pulmonary infiltrates, vascular engorgement, cardiomegaly, and pleural effusions. Three patients died from progressive respiratory failure despite ventilatory support. Pulmonary histology revealed thrombi composed of leukemic blast cells which obstructed and distended the lumens of pulmonary arterioles, capillaries, and venules. Electron microscopy studies of lung tissue showed pulmonary alveolar endothelium and basement membrane damage and interstitial edema. The pathophysiologic basis of pulmonary leukostasis and potential treatment modalities are discussed. |
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Authors:
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T J Myers; S R Cole; A U Klatsky; D H Hild |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer Volume: 51 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1808-13 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Female Hematologic Diseases / chemically induced, complications Humans Leukemia / drug therapy* Leukocytes / drug effects* Lung / blood supply, pathology Lung Diseases / chemically induced*, complications Male Middle Aged Respiratory Insufficiency / etiology* Time Factors |
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