Document Detail


Respiratory failure due to pulmonary leukostasis following chemotherapy of acute nonlymphocytic leukemia.
MedLine Citation:
PMID:  6831346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four patients with acute nonlymphocytic leukemia and leukocyte counts of more than 200,000/mm3 developed respiratory distress due to pulmonary leukostasis within 10-48 hours after initiation of chemotherapy. Clinically, the patients manifested fever, dyspnea, tachypnea, diffuse pulmonary rales, pleural effusions, and severe hypoxemia. Chest roentgenograms displayed diffuse pulmonary infiltrates, vascular engorgement, cardiomegaly, and pleural effusions. Three patients died from progressive respiratory failure despite ventilatory support. Pulmonary histology revealed thrombi composed of leukemic blast cells which obstructed and distended the lumens of pulmonary arterioles, capillaries, and venules. Electron microscopy studies of lung tissue showed pulmonary alveolar endothelium and basement membrane damage and interstitial edema. The pathophysiologic basis of pulmonary leukostasis and potential treatment modalities are discussed.
Authors:
T J Myers; S R Cole; A U Klatsky; D H Hild
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer     Volume:  51     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1808-13     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Aged
Female
Hematologic Diseases / chemically induced,  complications
Humans
Leukemia / drug therapy*
Leukocytes / drug effects*
Lung / blood supply,  pathology
Lung Diseases / chemically induced*,  complications
Male
Middle Aged
Respiratory Insufficiency / etiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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