Document Detail

Respiratory effort sensation during exercise with induced expiratory-flow limitation in healthy humans.
MedLine Citation:
PMID:  9292483     Owner:  NLM     Status:  MEDLINE    
Nine healthy subjects (age 31 +/- 4 yr) exercised with and without expiratory-flow limitation (maximal flow approximately 1 l/s). We monitored flow, end-tidal PCO2, esophageal (Pes) and gastric pressures, changes in end-expiratory lung volume, and perception (sensation) of difficulty in breathing. Subjects cycled at increasing intensity (+25 W/30 s) until symptom limitation. During the flow-limited run, exercise performance was limited in all subjects by maximum sensation. Sensation was equally determined by inspiratory and expiratory pressure changes. In both runs, 90% of the variance in sensation could be explained by the Pes swings (difference between peak inspiratory and peak expiratory Pes). End-tidal PCO2 did not explain any variance in sensation in the control run and added only 3% to the explained variance in the flow-limited run. We conclude that in healthy subjects, during normal as well as expiratory flow-limited exercise, the pleural pressure generation of the expiratory muscles is equally related to the perception of difficulty in breathing as that of the inspiratory muscles.
B Kayser; P Sliwinski; S Yan; M Tobiasz; P T Macklem
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  83     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-14     Completed Date:  1997-10-14     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  936-47     Citation Subset:  IM; S    
Meakins-Christie Laboratories, McGill University Clinics, Montreal, Quebec, Canada H2X 2P2.
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MeSH Terms
Carbon Dioxide / blood
Diaphragm / physiology
Exercise / physiology*
Exercise Test
Models, Biological
Regression Analysis
Respiratory Function Tests
Respiratory Mechanics / physiology*
Respiratory Muscles / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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