Document Detail


Respiratory effects of nitrous oxide during halothane or enflurane anaesthesia in children.
MedLine Citation:
PMID:  3284267     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The respiratory effects of nitrous oxide (N2O) were studied during halothane and enflurane anaesthesia in 12 children (mean age 46.4 +/- 29.3 months, mean weight 15.3 +/- 4.2 kg) during surgery under continuous extradural anaesthesia. Four equipotent anaesthetic states were studied in random order: 1) halothane 1 MAC in oxygen, 2) halothane 0.5 MAC + 50% N2O, 3) enflurane 1 MAC in oxygen, 4) enflurane 0.5 MAC +50% N2O. End-tidal fractions of CO2 (PetCO2) and halothane and enflurane were measured using infrared analysers. The respiratory variables (tidal volume VT, minute ventilation VE, respiratory frequency F, inspiratory time Ti, mean inspiratory flow VI, effective inspiratory time Ti/Ttot) were measured using a pneumotachograph. Significant changes were observed between the four states for VE, VI, F and PetCO2, whereas the values of VT, Ti and Ti/Tot did not differ significantly. The respiratory depressant effect of 1 MAC of either halothane alone or of the mixture of halothane and N2O was very similar. During enflurane anaesthesia, PetCO2 was less increased when N2O was substituted for enflurane, owing to a significant increase in respiratory frequency. A marked decrease in VE together with an increase in PetCO2 was observed during enflurane anaesthesia (states 3 and 4) when compared to the corresponding states during halothane anaesthesia (states 1 and 2). The respiratory depressant effect of enflurane is greater than that of halothane in unpremedicated children, even when substituting N2O for an equal MAC fraction of enflurane.2+ The effect of N2O on respiratory patterns seems to depend on the inhalational agent used and/or on the vesting respiratory frequency.
Authors:
I Murat; F Le Bret; M Chaussain; C Saint-Maurice
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  32     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  186-92     Citation Subset:  IM    
Affiliation:
Department of Anesthesiology, Hôpital Saint-Vincent-de-Paul, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Inhalation*
Child
Child, Preschool
Clinical Trials as Topic
Enflurane*
Halothane*
Humans
Infant
Nitrous Oxide*
Random Allocation
Respiration / drug effects*
Chemical
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane; 151-67-7/Halothane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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