Document Detail

Respiratory effects of intravenous midazolam.
MedLine Citation:
PMID:  8910727     Owner:  NLM     Status:  MEDLINE    
Thirty-four healthy, young-adult patients receiving intravenous midazolam for third-molar surgery had their respiratory parameters measured by respiratory inductive plethysmography. Tidal volume and minute volume showed significant changes during the initial 5-10 minutes of sedation, the changes being maximal during the first 5 minutes from the completion of injection of midazolam. The measurement of phase angle, an indicator of respiratory asynchrony, showed no significant change from normal, although a few patients showed some asynchrony of breathing, suggesting some amount of respiratory obstruction. A few patients showed a short period of apnoea and a small fall in the oxygen saturation. None of these changes caused any clinical concerns. It is suggested that the absence of stimulation after injection of midazolam, particularly in the initial few minutes, may contribute to the potential onset of respiratory problems.
M Zacharias; K M Hunter; R Parkinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New Zealand dental journal     Volume:  92     ISSN:  0028-8047     ISO Abbreviation:  N Z Dent J     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-02-13     Completed Date:  1997-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401065     Medline TA:  N Z Dent J     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  76-9     Citation Subset:  D; IM    
Department of Anaesthesia and Intensive Care, Dunedin School of Medicine, University of Otago, Dunedin.
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MeSH Terms
Airway Obstruction / chemically induced
Anesthesia, Dental
Anesthesia, Intravenous
Anesthetics, Intravenous / administration & dosage,  pharmacology*
Apnea / chemically induced
Conscious Sedation
Midazolam / administration & dosage,  pharmacology*
Molar, Third / surgery
Oxygen / blood
Respiration / drug effects*
Tidal Volume / drug effects
Tooth Extraction
Tooth, Impacted / surgery
Reg. No./Substance:
0/Anesthetics, Intravenous; 59467-70-8/Midazolam; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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