Document Detail

Respiratory effects of intrathecal capsaicin in arthritic and non-arthritic rats.
MedLine Citation:
PMID:  6203007     Owner:  NLM     Status:  MEDLINE    
The study determined the effects of intrathecal injection of 50 micrograms of capsaicin on respiration in rats with adjuvant arthritis as well as in control animals. Whole body plethysmographic measurements of steady-state frequency, tidal volume, and minute volume of respiration were made 3 hours and for up to 11 days after intrathecal injection. Capsaicin increased minute volume within 3 hours of its intrathecal injection in control animals. Intrathecal capsaicin also reduced the respiratory response to adjuvant arthritis in the experimental animals; the latter effect was apparent 11 days after injection. This biphasic pattern of capsaicin effects is consistent with a possible role of substance P in the chronic pain which is presumably associated with adjuvant arthritis in the rat.
K Bervoets; F C Colpaert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  34     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-07-25     Completed Date:  1984-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2477-83     Citation Subset:  IM    
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MeSH Terms
Arthritis / physiopathology*
Arthritis, Experimental / physiopathology*
Body Weight / drug effects
Capsaicin / administration & dosage,  pharmacology*
Injections, Spinal
Pain / physiopathology
Rats, Inbred Strains
Respiration / drug effects*
Substance P / secretion
Reg. No./Substance:
33507-63-0/Substance P; 404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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