Document Detail

Respiratory effects of exposure to diesel traffic in persons with asthma.
MedLine Citation:
PMID:  18057337     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Air pollution from road traffic is a serious health hazard, and people with preexisting respiratory disease may be at increased risk. We investigated the effects of short-term exposure to diesel traffic in people with asthma in an urban, roadside environment. METHODS: We recruited 60 adults with either mild or moderate asthma to participate in a randomized, crossover study. Each participant walked for 2 hours along a London street (Oxford Street) and, on a separate occasion, through a nearby park (Hyde Park). We performed detailed real-time exposure, physiological, and immunologic measurements. RESULTS: Participants had significantly higher exposures to fine particles (<2.5 microm in aerodynamic diameter), ultrafine particles, elemental carbon, and nitrogen dioxide on Oxford Street than in Hyde Park. Walking for 2 hours on Oxford Street induced asymptomatic but consistent reductions in the forced expiratory volume in 1 second (FEV1) (up to 6.1%) and forced vital capacity (FVC) (up to 5.4%) that were significantly larger than the reductions in FEV1 and FVC after exposure in Hyde Park (P=0.04 and P=0.01, respectively, for the overall effect of exposure, and P<0.005 at some time points). The effects were greater in subjects with moderate asthma than in those with mild asthma. These changes were accompanied by increases in biomarkers of neutrophilic inflammation (sputum myeloperoxidase, 4.24 ng per milliliter after exposure in Hyde Park vs. 24.5 ng per milliliter after exposure on Oxford Street; P=0.05) and airway acidification (maximum decrease in pH, 0.04% after exposure in Hyde Park and 1.9% after exposure on Oxford Street; P=0.003). The changes were associated most consistently with exposures to ultrafine particles and elemental carbon. CONCLUSIONS: Our observations serve as a demonstration and explanation of the epidemiologic evidence that associates the degree of traffic exposure with lung function in asthma.
James McCreanor; Paul Cullinan; Mark J Nieuwenhuijsen; James Stewart-Evans; Eleni Malliarou; Lars Jarup; Robert Harrington; Magnus Svartengren; In-Kyu Han; Pamela Ohman-Strickland; Kian Fan Chung; Junfeng Zhang
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New England journal of medicine     Volume:  357     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2007-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2348-58     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2007 Massachusetts Medical Society.
National Heart and Lung Institute, Imperial College, and Royal Brompton Hospital, London, United Kingdom.
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MeSH Terms
Air Pollutants / adverse effects*
Air Pollution / adverse effects,  analysis
Asthma / etiology*,  physiopathology
Cross-Over Studies
Environmental Exposure / adverse effects*,  analysis
Environmental Monitoring
Forced Expiratory Volume
Gasoline / adverse effects
Maximal Midexpiratory Flow Rate
Middle Aged
Nitrogen Dioxide / adverse effects*,  analysis
Particulate Matter / adverse effects*
Vehicle Emissions* / analysis
Vital Capacity
Reg. No./Substance:
0/Air Pollutants; 0/Gasoline; 0/Particulate Matter; 0/Vehicle Emissions; 10102-44-0/Nitrogen Dioxide
Comment In:
N Engl J Med. 2007 Dec 6;357(23):2395-7   [PMID:  18057343 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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