Document Detail

Respiratory effects of balloon occluded retrograde transvenous obliteration of gastric varices - A prospective controlled study.
MedLine Citation:
PMID:  21443664     Owner:  NLM     Status:  Publisher    
Background and Aim: We evaluated the respiratory effects of BRTO performed for the treatment of gastric varices complicating liver cirrhosis. Methods: From 2005 to 2009, we performed BRTO in 20 patients with gastric fundal varices, by intravariceal injection of 5% ethanolamine oleate (EO) as the sclerosant. We studied the effect of BRTO on the respiratory gas exchange, chest X-ray findings, CT findings, pulmonary function parameters, and (99m) Tc-MAA lung perfusion scintigraphy findings. Subjects undergoing balloon-occluded retrograde transvenous varicerography (BRTV) without injection of the sclerosant served as the controls. Results: Arterial blood gas analysis revealed a decrease in the mean arterial partial oxygen tension (PaO2) (P < 0.01), and increase in the alveolar-arterial oxygen tension difference (AaDO2) after BRTO (P < 0.01), as compared with the results obtained before the BRTO, while breathing room air. No changes were observed after BRTV as compared with the previous findings. In addition, a significant correlation was observed between the change of the PaO2 and the volume of the sclerosant injected (rs = 0.511, P = 0.011). Left- pleural effusion was noted on the chest CT in 20% of the patients. On pulmonary function testing, decrease of the vital capacity was noted in two of the 20 patients after BRTO. Conclusions: The aforementioned results suggest that BRTO performed using EO as the sclerosant induces pulmonary function disorders. The effect was found to depend on the total amount of EO injected. Therefore, careful respiratory monitoring seems necessary in patients undergoing BRTO, particularly those in whom large volumes of the sclerosant are used.
Hirotaka Arai; Takehiko Abe; Hisashi Takayama; Mitsuo Toyoda; Kazuyo Mori; Takashi Ueno; Hitoshi Takagi; Ryuya Shimoda
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-28
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  -     ISSN:  1440-1746     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Department of Gastroenterology, Maebashi Red Cross Hospital, 3-21-36 Asahi-cho, Maebashi, Gunma 371-0014, Japan E-mail: Telephone: 027-2244585 Fax: 027-2433380 Department of Gastroenterology, Maebashi Red Cross Hospital, Maebashi, Gunma, Japan Department of Gastroenterology, Takasaki Hospital, Takasaki, Gunma, Japan Shimoda Medical Clinic, Maebashi, Gunma, Japan.
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