Document Detail

Respiratory effects of TRH in preterm rabbits.
MedLine Citation:
PMID:  6810296     Owner:  NLM     Status:  MEDLINE    
The respiratory activity in newborn preterm (29 days gestation) rabbits was studied after administration of thyrotropic releasing hormone. Intraperitoneal injection induced an increase in respiratory frequency (f) and a decrease in tidal volume (VT) resulting in a slight increase in pulmonary ventilation (VE). These effects were seen in parallel to a decrease in expiratory time (TE) and respiratory time (TTOT). An increase in the TI/TTOT ratio but (unaffected) VT/TI ratio indicates that thyrotropic releasing hormone affects "respiratory timing" mechanisms rather than "inspiratory drive." The changes in respiratory parameters are most probably due to an effect on the central respiratory controlling centers in the brain stem.
T Hedner; J Hedner; J Jonason; D Lundberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  16     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-8     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn / physiology
Carbon Dioxide / pharmacology
Fetus / physiology
Gestational Age
Respiration / drug effects*
Thyrotropin-Releasing Hormone / pharmacology*
Tidal Volume
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 24305-27-9/Thyrotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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