Document Detail

Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia.
MedLine Citation:
PMID:  6356758     Owner:  NLM     Status:  MEDLINE    
THIP, 4, 5, 6, 7-tetrahydroisoxazolo (5,4-) pyridin-3-ol, is a GABA-agonistic drug with analgesic effect, but apparently without respiratory depressant properties in awake subjects. The effect of THIP on the CO2 ventilation response was tested before, during and at the end of halothane anaesthesia in six male patients and compared to a control group. As there was no indication of respiratory depression by THIP, the drug may have a future in the treatment of postoperative pain if an analgesic effect is confirmed under clinical conditions.
N Valentin; O K Bank-Mikkelsen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  27     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  366-8     Citation Subset:  IM    
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MeSH Terms
Analgesics / pharmacology*
Anesthesia, Inhalation*
Clinical Trials as Topic
Halothane / therapeutic use*
Isoxazoles / pharmacology*
Middle Aged
Oxazoles / pharmacology*
Respiration / drug effects*
Reg. No./Substance:
0/Analgesics; 0/Isoxazoles; 0/Oxazoles; 151-67-7/Halothane; 64603-91-4/4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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