Document Detail


Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia.
MedLine Citation:
PMID:  6356758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
THIP, 4, 5, 6, 7-tetrahydroisoxazolo (5,4-) pyridin-3-ol, is a GABA-agonistic drug with analgesic effect, but apparently without respiratory depressant properties in awake subjects. The effect of THIP on the CO2 ventilation response was tested before, during and at the end of halothane anaesthesia in six male patients and compared to a control group. As there was no indication of respiratory depression by THIP, the drug may have a future in the treatment of postoperative pain if an analgesic effect is confirmed under clinical conditions.
Authors:
N Valentin; O K Bank-Mikkelsen
Related Documents :
11810038 - Use of tts fentanyl as a single opioid for cancer pain relief: a safety and efficacy cl...
17367258 - Naloxone treatment in opioid addiction: the risks and benefits.
4014618 - Plasma bupivacaine levels associated with extradural anaesthesia for caesarean section.
9762758 - Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after...
17054208 - Valerian for anxiety disorders.
22386968 - Structural deficits in the emotion circuit and cerebellum are associated with depressio...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  27     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  366-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analgesics / pharmacology*
Anesthesia, Inhalation*
Clinical Trials as Topic
Halothane / therapeutic use*
Humans
Isoxazoles / pharmacology*
Male
Middle Aged
Oxazoles / pharmacology*
Respiration / drug effects*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Isoxazoles; 0/Oxazoles; 151-67-7/Halothane; 64603-91-4/4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Differential lung ventilation with unilateral PEEP following unilateral hydrochloric acid aspiration...
Next Document:  Measurement of cardiac stroke volume during cesarean section: a comparison between impedance cardiog...