Document Detail

Respiratory dysfunction in sleep apnea associated with quetiapine.
MedLine Citation:
PMID:  18484556     Owner:  NLM     Status:  MEDLINE    
Quetiapine is an atypical antipsychotic with good tolerability, but has recently been associated with respiratory dysfunction. The aim of this work is to report on moderate to severe respiratory dysfunction after normal oral doses of quetiapine in two obese patients with sleep apnea syndrome (SAS). In the first case, acute respiratory failure and coma occurred after a single normal oral dose of quetiapine in combination with lorazepam (although even higher doses of lorazepam alone were tolerated) in a patient with previously unknown SAS. Intensive care treatment and mechanical ventilation led to full recovery. The second case was a patient with an operated obstructive SAS in which quetiapine was associated with nocturnal respiratory dysfunction and confusion. Respiratory function should be monitored when using quetiapine in patients with possible sleep apnea, particularly in obese patients and when given in combination with benzodiazepines.
R W Freudenmann; S D Süssmuth; R C Wolf; P Stiller; C Schönfeldt-Lecuona
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Publication Detail:
Type:  Case Reports; Letter    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  41     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  119-21     Citation Subset:  IM    
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MeSH Terms
Antipsychotic Agents / therapeutic use*
Dibenzothiazepines / therapeutic use*
Middle Aged
Respiration / drug effects*
Sleep Apnea Syndromes / drug therapy*,  physiopathology*
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/quetiapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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