Document Detail


Respiratory distress syndrome and inositol supplementation in preterm infants.
MedLine Citation:
PMID:  3539028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report a randomised double blind trial of myo-inositol (inositol) supplementation for 10 days in 74 preterm infants with a birth weight less than 2000 g (mean gestational age 29.5 weeks and mean birth weight 1266 g). All infants required artificial ventilation for treatment of respiratory distress syndrome. Inositol (120-160 mg/kg/day) was administered by the ingastric or intravenous route. The 37 infants who received inositol supplementation required less mechanical ventilation during days 4-10, had less failures of indomethacin to close ductus arteriosus, and had less deaths or bronchopulmonary dysplasia, or both, than the infants treated with placebo. There were no detectable adverse effects. These preliminary results suggest that inositol is an important nutrient in immature preterm infants.
Authors:
M Hallman; A L Järvenpää; M Pohjavuori
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  61     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-01-20     Completed Date:  1987-01-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1076-83     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Double-Blind Method
Gestational Age
Humans
Infant, Newborn
Inositol / therapeutic use*
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / drug therapy*,  mortality,  therapy
Chemical
Reg. No./Substance:
6917-35-7/Inositol
Comments/Corrections

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