| Respiratory depression of intravenous hydroxyzine in man: potency, duration, and lack of reversal by naloxone. | |
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MedLine Citation:
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PMID: 7196705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of intravenous hydroxyzine and hydroxyzine with naloxone on respiration were determined in man. Drug effect was expressed as the shift in the 20-L intercept of the respiratory response curve measured by a rebreathing technique. The time-effect curve of hydroxyzine was found to be the same for hydroxyzine alone and in combination with naloxone, but significantly different from placebo or naloxone alone. The duration of respiratory depression in man resulting from hydroxyzine, 100 mg IV, is greater than 3 hours. Our data did not support the hypothesis that the respiratory depressant and recently discovered antinociceptive effects of hydroxyzine result from endorphin release or are mediated by opiate receptors. |
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Authors:
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M L Gabathuler; R D Kaufman |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 60 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1981 Sep |
Date Detail:
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Created Date: 1981-10-14 Completed Date: 1981-10-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 634-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Depression, Chemical Endorphins / metabolism Humans Hydroxyzine / adverse effects*, antagonists & inhibitors Infusions, Parenteral Male Naloxone / pharmacology* Respiration / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Endorphins; 465-65-6/Naloxone; 68-88-2/Hydroxyzine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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