Document Detail


Respiratory depression of intravenous hydroxyzine in man: potency, duration, and lack of reversal by naloxone.
MedLine Citation:
PMID:  7196705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of intravenous hydroxyzine and hydroxyzine with naloxone on respiration were determined in man. Drug effect was expressed as the shift in the 20-L intercept of the respiratory response curve measured by a rebreathing technique. The time-effect curve of hydroxyzine was found to be the same for hydroxyzine alone and in combination with naloxone, but significantly different from placebo or naloxone alone. The duration of respiratory depression in man resulting from hydroxyzine, 100 mg IV, is greater than 3 hours. Our data did not support the hypothesis that the respiratory depressant and recently discovered antinociceptive effects of hydroxyzine result from endorphin release or are mediated by opiate receptors.
Authors:
M L Gabathuler; R D Kaufman
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  60     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-10-14     Completed Date:  1981-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  634-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Depression, Chemical
Endorphins / metabolism
Humans
Hydroxyzine / adverse effects*,  antagonists & inhibitors
Infusions, Parenteral
Male
Naloxone / pharmacology*
Respiration / drug effects*
Chemical
Reg. No./Substance:
0/Endorphins; 465-65-6/Naloxone; 68-88-2/Hydroxyzine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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