Document Detail


Respiratory control during exercise in patients with cardiovascular disease.
MedLine Citation:
PMID:  8430969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathophysiologic mechanism for exertional dyspnea, the main symptom of patients with heart failure, has not been fully clarified. To determine the relationship between exercise hyperpnea and the lactic acidosis in patients with heart failure, we evaluated ventilation during incremental exercise both below and above the lactic acidosis threshold in 16 normal subjects and in 48 patients with cardiovascular disease while expired gas was analyzed continuously. The peak oxygen uptake and oxygen uptake at the lactic acidosis threshold decreased significantly as the New York Heart Association (NYHA) functional class severity increased. the slope of the increase in ventilation to the increase in oxygen uptake (delta VE/delta VO2) at work rates below the lactic acidosis threshold did not differ between normal subjects and patients with heart failure. Above the lactic acidosis threshold, however, the slope of delta VE/delta VO2, which was higher than that below the lactic acidosis threshold in each of four groups, was steeper in patients in NYHA Class II (60.8 +/- 17.9) and Class III (66.5 +/- 21.2) when compared with that in the normal subjects (46.6 +/- 13.5) or the patients in NYHA Class I (46.1 +/- 10.3). The lactic acidosis caused by decreased oxygen transport to working muscles accounts for the higher ventilation during exercise in cardiac patients. These data suggest that the increased ventilation during exercise, which must be related to exertional dyspnea, in patients with cardiovascular disease is primarily the consequence of a stimulus to regulate arterial pH.
Authors:
A Koike; M Hiroe; K Taniguchi; F Marumo
Related Documents :
7998879 - Do we really need pulse? chronic nonpulsatile and pulsatile blood flow: from the exerci...
9784909 - Acute and chronic effects of propionyl-l-carnitine on the hemodynamics, exercise capaci...
7579049 - Exercise-induced acute renal failure associated with ibuprofen, hydrochlorothiazide, an...
20446069 - Electrical muscle stimulation for chronic heart failure: an alternative tool for exerci...
19837829 - Determinants of postexercise heart rate recovery in patients with the obstructive sleep...
8430969 - Respiratory control during exercise in patients with cardiovascular disease.
15833369 - In vivo corticosterone administration at levels occurring with intense exercise does no...
1483749 - Carbohydrate feeding during exercise.
21975419 - Persons with multiple sclerosis show altered joint kinetics during walking after partic...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  147     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-09     Completed Date:  1993-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  AIM; IM; S    
Affiliation:
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acidosis, Lactic / epidemiology,  physiopathology
Aged
Analysis of Variance
Breath Tests
Cardiovascular Diseases / epidemiology,  physiopathology*
Exercise / physiology*
Exercise Test / instrumentation,  methods,  statistics & numerical data
Female
Humans
Male
Middle Aged
Oxygen Consumption / physiology
Respiration / physiology*
Respiratory Mechanics / physiology
Comments/Corrections
Comment In:
Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):1146-7   [PMID:  8214935 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Diagnosis of primary tuberculosis in children by amplification and detection of mycobacterial DNA.
Next Document:  Ultrasound study in unilateral hemithorax opacification. Image comparison with computed tomography.