Document Detail

Respiratory control during exercise: hormones, osmolality, strong ions, and PaCO2.
MedLine Citation:
PMID:  8000357     Owner:  NLM     Status:  MEDLINE    
For optimal performance of exercising muscle, the charge state of proteins must be maintained; the pH environment of protein histidine imidazole groups must be coordinated with their pK. During exercise, increasing temperature and osmolality as well as changes in strong ions affect the pK of imidazole groups. Production of strong organic anions also decreases the concentration difference between strong cations and anions (strong ion difference, or [SID]), causing a metabolic acidosis in peripheral tissues. Central chemoreceptors regulate PCO2 in relation to the [SID] of brain fluids to maintain a "constant" brain [H+]. In addition, increased osmolality, angiotensin II, and vasopressin during exercise may stimulate circumventricular organs of the brain and interact with chemical control of ventilation. Changes in [SID] of brain fluids during exercise are negligible compared to systemic decreases in [SID]; thus, regulation of PCO2 to maintain brain [H+] homeostasis cannot simultaneously compensate for greater changes in [SID] in peripheral tissues.
D B Jennings
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  19     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-24     Completed Date:  1995-01-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  334-49     Citation Subset:  IM; S    
Department of Physiology, Queen's University, Kingston, Ontario.
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MeSH Terms
Acid-Base Equilibrium / physiology
Acidosis / physiopathology
Exercise / physiology*
Homeostasis / physiology*
Hydrogen-Ion Concentration
Osmolar Concentration
Physical Conditioning, Animal / physiology
Respiration / physiology*
Vasopressins / physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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