Document Detail

Respiratory compensation point during incremental exercise as related to hypoxic ventilatory chemosensitivity and lactate increase in man.
MedLine Citation:
PMID:  11082544     Owner:  NLM     Status:  MEDLINE    
The pulmonary ventilation-O2 uptake (VE-VO2) relationship during incremental exercise has two inflection points: one at a lower VO2, termed the ventilatory threshold (VT); and another at a higher VO2, the respiratory compensation point (RCP). The individuality of RCP was studied in relation to those of the chemosensitivities of the central and peripheral chemoreceptors, which were assessed by resting estimates of hypercapnic ventilatory response (HCVR) and hypoxic ventilatory response (HVR), respectively, and the rate of lactic acid increase during exercise, which was estimated as a slope difference (delta slope) between a lower slope of VCO2-VO2 relationship (VCO2:CO2 output) obtained at work rates below VT and a higher slope at work rates between VT and RCP. Twenty-two male and sixteen female subjects underwent a 1 min incremental exercise test until exhaustion, in which VT, RCP and delta slope were determined. All measures were normalized for body surface area. In the males, the individual difference in RCP was inversely correlated with those of HVR and delta slope (p < 0.05), and in the females, similar tendencies persisted, while the correlation did not reach statistically significant levels (0.05 < p < 0.1). There was no significant correlation between RCP and HCVR in either sex. A multiple linear regression analysis showed that 40 to 50% of the variance of RCP was accounted for by those of HVR and delta slope, both of which were related linearly and additively to RCP, this relation being manifested in the males but not in the females without consideration of the menstrual cycle. These results suggest that the individuality of RCP depends partly on the chemosensitivity of the carotid bodies and the rate of lactic acid increase during incremental exercise.
N Takano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  50     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-02-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  449-55     Citation Subset:  IM    
Physiology Laboratory, Department of School Health, Faculty of Education, Kanazawa University, Kanazawa, 920-1192 Japan.
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MeSH Terms
Acidosis, Lactic / physiopathology
Anoxia / physiopathology*
Carbon Dioxide / analysis
Carotid Body / physiology*
Hypercapnia / physiopathology
Lactic Acid / blood*
Linear Models
Oxygen / analysis
Physical Exertion / physiology*
Pulmonary Gas Exchange / physiology*
Pulmonary Ventilation
Reg. No./Substance:
124-38-9/Carbon Dioxide; 50-21-5/Lactic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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