Document Detail

Respiratory clearance of aerosolized radioactive solutes of varying molecular weight.
MedLine Citation:
PMID:  2437269     Owner:  NLM     Status:  MEDLINE    
To determine the influence of varying molecular weight (mol wt) on respiratory clearance of aerosolized solutes, we studied eight radiopharmaceuticals, each administered to four dogs: sodium 99mTc pertechnetate (TcO4), 99mTc glucoheptonate ([99mTc]GH), 51Cr-ethylenedinitrotetraacetate ([51Cr]EDTA), 99mTc diethylenetriaminepentaacetate ([99mTc] DTPA), 111In diethylenetriaminepentaacetate ([111In]DTPA), 67Ga desferoxaminemesylate ([67Ga]DFOM), 99mTc dextran ([99mTc]DX) and 111In transferrin ([111In]TF). After aerosolization (0.8 m MMD, 2.4 GSD), clearance was determined for 30 min and then corrected by intravenous injection for nonairspace radioactivity. In-TF clearance (0.11 +/- 0.10%/min) was lower than TcO4 (6.32 +/- 0.62%/min), [99mTc]GH (1.50 +/- 0.37%/min), [51Cr]EDTA (2.38 +/- 1.02%/min), [99mTc]DTPA (3.51 +/- 0.40%/min), [111In]DTPA (2.35 +/- 0.42%/min), [67Ga] DFOM (1.99 +/- 0.49%/min) and [99mTc]DX (1.81 +/- 0.75%/min) clearances (p less than 0.001). TcO4 clearance was higher than others (p less than 0.001). Technetium binding to DX was unsatisfactory; aerosolization caused unbinding from DTPA. We conclude that respiratory clearance of large mol wt solutes within 30 min is negligible and, that clearance of molecules between 347-5,099 daltons differs greatly, suggesting that binding and/or intrapulmonary retention affect transfer.
G J Huchon; A B Montgomery; A Lipavsky; J M Hoeffel; J F Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  28     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  894-902     Citation Subset:  IM    
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MeSH Terms
Chromium Radioisotopes
Deferoxamine / metabolism*
Dextrans / metabolism*
Edetic Acid / metabolism*
Gallium Radioisotopes
Lung / metabolism*,  radionuclide imaging
Pentetic Acid / metabolism*
Sugar Acids / metabolism*
Transferrin / metabolism*
Grant Support
Reg. No./Substance:
0/Chromium Radioisotopes; 0/Gallium Radioisotopes; 0/Sugar Acids; 11096-37-0/Transferrin; 60-00-4/Edetic Acid; 67-43-6/Pentetic Acid; 70-51-9/Deferoxamine; 7440-26-8/Technetium; 7440-74-6/Indium; 87-74-1/alpha-glucoheptonic acid; 9004-54-0/Dextrans

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