| Respiratory and cerebrovascular responses to hypoxia and hypercapnia in familial dysautonomia. | |
| | |
MedLine Citation:
|
PMID: 12406829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although cardiorespiratory complications contribute to the high morbidity/mortality of familial dysautonomia (FD), the mechanisms remain unclear. We evaluated respiratory, cardiovascular, and cerebrovascular control by monitoring ventilation, end-tidal carbon dioxide (CO2-et), oxygen saturation, RR interval, blood pressure (BP), and midcerebral artery flow velocity (MCFV) during progressive isocapnic hypoxia, progressive hyperoxic hypercapnia, and during recovery from moderate hyperventilation (to simulate changes leading to respiratory arrest) in 22 subjects with FD and 23 matched control subjects. Subjects with FD had normal ventilation, higher CO2-et, lower oxygen saturation, lower RR interval, and higher BP. MCFV was also higher but depended on the higher baseline CO2-et. In the FD group, whereas hyperoxic hypercapnia induced normal cardiovascular and ventilatory responses, progressive hypoxia resulted in blunted increases in ventilation, paradoxical decreases in RR interval and BP, and lack of MCFV increase. Hyperventilation induced a longer hypocapnia-induced apneic period (51.5 +/- 9.9 versus 11.2 +/- 5.5 seconds, p < 0.008) with profound desaturation (to 75.8 +/- 3.5%), marked BP decrease, and RR interval increase. Subjects with FD develop central depression in response to even moderate hypoxia with lack of expected change in cerebral circulation, leading to hypotension, bradycardia, hypoventilation, and potentially respiratory arrest. Higher resting BP delays occurrence of syncope during hypoxia. Therapeutic measures preventing hypoxia/hypocapnia may correct cardiovascular accidents in patients with FD. |
| | |
Authors:
|
Luciano Bernardi; Max Hilz; Brigitte Stemper; Claudio Passino; Goetz Welsch; Felicia B Axelrod |
Related Documents
:
|
7772429 - Halothane affects ventilatory afterdischarge in humans. 15319419 - Chronic intermittent hypoxia enhances cat chemosensory and ventilatory responses to hyp... 8458799 - Ventilatory response to moderate hypoxia in awake chemodenervated cats. 23432169 - Is the association between salt intake and blood pressure mediated by body mass index a... 7200769 - Altitude and hypoxia as phase shift inducers. 3140129 - Altered lung vascular permeability during intermittent haemodialysis. 23257249 - High-frequency jet ventilation during video-assisted thoracoscopic surgery in apatient ... 3258359 - Risk factors for hypertension: results from a cross-sectional survey. 7270949 - Epinephrine-induced arrhythmias and cardiovascular function after verapamil during halo... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2002-10-24 |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 167 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2003-01-13 Completed Date: 2003-02-13 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 141-9 Citation Subset: AIM; IM |
Affiliation:
|
New York University Medical Center, New York University School of Medicine, New York, USA. lbern1ps@unipv.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological* Adolescent Adult Anoxia / etiology, physiopathology* Blood Pressure Determination Case-Control Studies Cerebrovascular Circulation / physiology Chemoreceptor Cells / physiology* Child Dysautonomia, Familial / complications*, diagnosis, mortality Female Humans Hypercapnia / etiology, physiopathology* Hypotension / diagnosis, physiopathology Male Middle Aged Oxygen Consumption / physiology* Probability Pulmonary Gas Exchange Reference Values Respiratory Mechanics Risk Assessment Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes.
Next Document: Alveolar macrophages have a protective antiinflammatory role during murine pneumococcal pneumonia.