Document Detail

Respiratory and cardiovascular responses to PEEP in artificially ventilated patients after cardiopulmonary bypass surgery.
MedLine Citation:
PMID:  7032349     Owner:  NLM     Status:  MEDLINE    
The respiratory and haemodynamic effects of incremental levels of positive and expiratory pressure (PEEP) to 9 cm H2O were studied in ten adult patients 3--6 hours after uneventful cardiopulmonary bypass surgery. Functional residual capacity was increased and deadspace-tidal volume ratio tended to fall, the latter approaching significance at +6 and +9 cm PEEP. Thus lung volume was increased and there was a tendency to improved gas distribution to the alveoli. However there was no significant change in PaO2, alveolar-arterial oxygen tension difference or venous admixture. Cardiac index, and left ventricular strokework index were marginally depressed at 6 cm PEEP and further at 9 cm, while right atrial pressure and pulmonary artery occlusion pressure were raised at 9 cm PEEP. It would appear that low levels (3--6 cm) of PEEP do not improve gas exchange in the lungs to any worthwhile degree, and levels (6--9 cm) may impair cardiac performance.
T L Dobbinson; J R Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  9     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1981 Nov 
Date Detail:
Created Date:  1982-02-22     Completed Date:  1982-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  307-13     Citation Subset:  IM    
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MeSH Terms
Cardiopulmonary Bypass*
Functional Residual Capacity
Intermittent Positive-Pressure Ventilation
Lung Compliance
Middle Aged
Positive-Pressure Respiration*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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