| Respiratory and cardiovascular effects of doxapram and theophylline for the treatment of asphyxia in neonatal calves. | |
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MedLine Citation:
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PMID: 20022095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory stimulants are widely used in asphyxic neonatal calves despite a lack of data about their effectiveness and indications of possible side effects. The effect of doxapram and theophylline on respiratory, cardiovascular, and acid-base variables was investigated in 10 healthy neonatal calves (Bos Taurus). A venous, a peripheral arterial, and a pulmonary arterial catheter were placed, and central venous, pulmonary, and systemic blood pressures and cardiac output were measured using thermodilution technique. Doxapram, but not theophylline, led to an immediate increase in respiratory rate (P <or= 0.01). The arterial pCO(2) decreased to 27.1+/-4.7 mm Hg within 30 sec after doxapram administration and to 46.3+/-5.8 mm Hg within 120 min after theophylline administration (P<0.0001). The systolic pulmonary pressure increased from 70+/-8mm Hg (mean+/-SD) to 93+/-19 mm Hg within 30 sec after doxapram, but decreased after theophylline. The pulmonary vascular resistance also increased after doxapram and decreased after theophylline (P<0.01). Doxapram had a more pronounced and faster effect on respiratory rate and elimination of CO(2) than theophylline. Doxapram, but not theophylline, is indicated for treatment of postnatal asphyxia in calves, but there are potential cardiovascular side effects. |
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Authors:
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U Bleul; B Bircher; R S Jud; A P N Kutter |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Theriogenology Volume: 73 ISSN: 1879-3231 ISO Abbreviation: Theriogenology Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0421510 Medline TA: Theriogenology Country: United States |
Other Details:
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Languages: eng Pagination: 612-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Clinic of Reproductive Medicine, Department of Food Animals, Vetsuisse-Faculty University of Zurich, Zurich, Switzerland. ubleul@vetclinics.uzh.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn* Asphyxia / drug therapy*, physiopathology, veterinary Blood Pressure / drug effects Cardiovascular System / drug effects* Cattle Doxapram / pharmacology, therapeutic use* Female Heart Rate / drug effects Male Pulmonary Circulation / drug effects Respiratory Rate / drug effects Respiratory System / drug effects* Respiratory System Agents / pharmacology, therapeutic use Single-Blind Method Theophylline / pharmacology, therapeutic use* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Respiratory System Agents; 309-29-5/Doxapram; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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