Document Detail

Respiratory and cardiac responses to exercise-simulating peripheral perfusion in endurance trained and untrained rats. II. Temporal relationships between outflow parameters and cardiac and respiratory responses.
MedLine Citation:
PMID:  3203655     Owner:  NLM     Status:  MEDLINE    
In endurance trained (TR) and untrained (UTR) rats heart rate (HR) and respiratory rate (RR) were recorded during perfusion of the circulatorily isolated hind leg of the rat with exercise simulating modified tyrode solutions (TR:n = 10, UTR:n = 10; compare part I). During the 20 min test period and the preceding and succeeding periods of control perfusions with an unmodified tyrode solution, [lactate], pH, [K+], [Na+], PO2 and PCO2 were measured in the outflow of the femoral vein. In 3 experimental series: (1) hypoxic tyrode solution enriched with lactic acid (15 mmol.l-1), (2) normoxic solution with lactic acid, (3) hypoxic solution without lactic acid, were applied. The outflow parameters were cross correlated with both HR and RR. The analysis revealed a significant temporal relationship between [lactate], pH, PO2, PCO2 and [K+] and both HR and RR. In the trained rats no temporal correlation between either of the outflow and reflex parameters could be determined. This result was not due to low [lactate], but was also found during perfusion with lactic acid. In all 3 test conditions [lactate] in untrained individuals was best correlated with both HR and RR. Although the correlation peaks of the respiratory response, but not of the HR response were definitely lower in normoxic lactic and perfusion than in the two other experimental conditions, both inter- and intraindividual correlation analyses revealed a high degree of interdependence between respiratory and cardiac responses.
F Thimm; B Gerber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  58     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-31     Completed Date:  1989-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM; S    
Physiologisches Institut der Deutschen Sporthochschule Köln, Federal Republic of Germany.
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MeSH Terms
Anoxia / physiopathology
Heart / physiology*
Heart Rate
Hydrogen-Ion Concentration
Isotonic Solutions / diagnostic use
Lactates / blood,  pharmacology
Physical Conditioning, Animal*
Physical Endurance*
Physical Exertion*
Rats, Inbred Strains
Time Factors
Reg. No./Substance:
0/Isotonic Solutions; 0/Lactates; 0/Tyrode's solution

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