| Respiratory and cardiac responses to exercise-simulating peripheral perfusion in endurance trained and untrained rats. II. Temporal relationships between outflow parameters and cardiac and respiratory responses. | |
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MedLine Citation:
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PMID: 3203655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In endurance trained (TR) and untrained (UTR) rats heart rate (HR) and respiratory rate (RR) were recorded during perfusion of the circulatorily isolated hind leg of the rat with exercise simulating modified tyrode solutions (TR:n = 10, UTR:n = 10; compare part I). During the 20 min test period and the preceding and succeeding periods of control perfusions with an unmodified tyrode solution, [lactate], pH, [K+], [Na+], PO2 and PCO2 were measured in the outflow of the femoral vein. In 3 experimental series: (1) hypoxic tyrode solution enriched with lactic acid (15 mmol.l-1), (2) normoxic solution with lactic acid, (3) hypoxic solution without lactic acid, were applied. The outflow parameters were cross correlated with both HR and RR. The analysis revealed a significant temporal relationship between [lactate], pH, PO2, PCO2 and [K+] and both HR and RR. In the trained rats no temporal correlation between either of the outflow and reflex parameters could be determined. This result was not due to low [lactate], but was also found during perfusion with lactic acid. In all 3 test conditions [lactate] in untrained individuals was best correlated with both HR and RR. Although the correlation peaks of the respiratory response, but not of the HR response were definitely lower in normoxic lactic and perfusion than in the two other experimental conditions, both inter- and intraindividual correlation analyses revealed a high degree of interdependence between respiratory and cardiac responses. |
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Authors:
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F Thimm; B Gerber |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of applied physiology and occupational physiology Volume: 58 ISSN: 0301-5548 ISO Abbreviation: Eur J Appl Physiol Occup Physiol Publication Date: 1988 |
Date Detail:
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Created Date: 1989-01-31 Completed Date: 1989-01-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0410266 Medline TA: Eur J Appl Physiol Occup Physiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 112-9 Citation Subset: IM; S |
Affiliation:
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Physiologisches Institut der Deutschen Sporthochschule Köln, Federal Republic of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / physiopathology Heart / physiology* Heart Rate Hydrogen-Ion Concentration Isotonic Solutions / diagnostic use Lactates / blood, pharmacology Perfusion* Physical Conditioning, Animal* Physical Endurance* Physical Exertion* Rats Rats, Inbred Strains Respiration* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Isotonic Solutions; 0/Lactates; 0/Tyrode's solution |
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