Document Detail

Respiratory and cardiac responses to exercise-simulating peripheral perfusion in endurance trained and untrained rats. I. Reflex responses and changes in perfusion outflow.
MedLine Citation:
PMID:  3203654     Owner:  NLM     Status:  MEDLINE    
Ventilatory and circulatory drives elicited by exercise-simulating perfusion of the circulatory isolated hindleg were examined in 10 trained (TR) and untrained (UTR) rats. TR were submitted to endurance training on a motordriven treadmill (30.min-1 at a grade of 10%, 5 days a week for 30 min). Exercise was simulated by perfusion with modified tyrode solutions: I.) hypoxic, enriched with lactic acid (15 mmol.l-1), II.) normoxic, enriched with lactic acid. III.) hypoxic without lactic acid. Perfusion was performed in anaesthetized animals through cannulae in the femoral artery and vein; the hindled was connected to the rest of the body only by nerve and bone. 10 min of control perfusion (normoxic tyrode solution) was followed by a 20 min test period and another 10 min control perfusion. Apart from heart rate (HR), respiratory rate (RR) and several outflow parameters were measured ([K+], [Na+], [lactate], pH, PO2, PCO2). During control period HR was slightly higher in UTR than in TR (375.5 +/- 3.9 (SE) vs. 364.1 +/- 5.5 beats/min-1, p less than 0.6 n.s.), and RR in UTR was significantly higher than those in TR (61.5 +/- 0.4 bpm vs. 55.5 +/- 3.9 breaths.min-1, p less than 0.001). During the test periods both HR and RR in UTR increased significantly while in TR they did not (e.g. in series I mean HR and RR in UTR increased by 8.9 +/- 1.2 beats.min-1 and 1.4 +/- 0.1 breaths.min-1 respectively, whereas in TR the changes were - 2.9 +/- 1.5 beats/min-1 and -0.8 +/- 0.2 breaths.min-1.(ABSTRACT TRUNCATED AT 250 WORDS)
F Thimm; B Gerber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  58     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1988  
Date Detail:
Created Date:  1989-01-31     Completed Date:  1989-01-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM; S    
Physiologisches Institut der Deutschen Sporthochschule Köln, Federal Republic of Germany.
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MeSH Terms
Anoxia / physiopathology
Heart / physiology*
Heart Rate
Hydrogen-Ion Concentration
Isotonic Solutions / diagnostic use
Lactates / blood,  pharmacology
Oxygen Consumption
Physical Conditioning, Animal*
Physical Endurance*
Physical Exertion*
Rats, Inbred Strains
Reflex / physiology
Reg. No./Substance:
0/Isotonic Solutions; 0/Lactates; 0/Tyrode's solution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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