Document Detail

Respiratory alkalosis attenuates thromboxane-induced pulmonary hypertension.
MedLine Citation:
PMID:  3191739     Owner:  NLM     Status:  MEDLINE    
Mechanically induced respiratory alkalosis decreases pulmonary arterial pressure in infants with persistent pulmonary hypertension of the newborn and in newborn lambs with hypoxia-induced pulmonary hypertension. Since thromboxane A2 may mediate the pulmonary hypertension in infants with Group B beta-hemolytic streptococci and Escherichia coli pneumonia, we studied the effect of respiratory alkalosis on thromboxane-induced pulmonary hypertension. A specific thromboxane A2-mimetic, U46619, was infused into six normoxic, sedated, mechanically ventilated lambs. U46619 produced pulmonary hypertension which was significantly attenuated during respiratory alkalosis. These results support the use of respiratory alkalosis to treat infants and children with pulmonary hypertension regardless of the presumed etiology.
M D Schreiber; S J Soifer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Critical care medicine     Volume:  16     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-10     Completed Date:  1989-01-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1225-8     Citation Subset:  AIM; IM    
Cardiovascular Research Institute, University of California, San Francisco, 94143-0106.
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MeSH Terms
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Alkalosis, Respiratory / physiopathology*
Animals, Newborn
Blood Pressure
Hydrogen-Ion Concentration
Hypertension, Pulmonary / chemically induced,  therapy*
Oxygen / metabolism
Prostaglandin Endoperoxides, Synthetic
Respiration, Artificial
Grant Support
Reg. No./Substance:
0/Prostaglandin Endoperoxides, Synthetic; 76898-47-0/15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 7782-44-7/Oxygen

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